Anesthesiology 2001 Aug;95(2):569-70
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PMID: 11506143, UI: 21396943
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Anesthesiology 2001 Aug;95(2):567-8
PMID: 11506141, UI: 21396941
Anesthesiology 2001 Aug;95(2):562-4
Department of Anesthesia, University of California, San Francisco, USA. rampil@anesthes.sunysb.edu
PMID: 11506137, UI: 21396937
Anesthesiology 2001 Aug;95(2):553-5
Department of Anesthesiology, Stanford University School of Medicine, California 94305-5640, USA. eratner@leland.stanford.edu
PMID: 11506134, UI: 21396934
Anesthesiology 2001 Aug;95(2):531-43
Outcomes Research Institute and Department of Anesthesiology, University of Louisville, Kentucky 40202-3866, USA. sessler@louisville.edu
PMID: 11506130, UI: 21396930
Anesthesiology 2001 Aug;95(2):371-6
Department of Anesthesiology, University of Florida, College of Medicine, Gainesville 32610, USA. froelich@anest1.ufl.edu
BACKGROUND: In recent years, the concept of prophylactic volume expansion to prevent hypotension caused by spinal anesthesia has been challenged. Investigators have reevaluated the concept of prehydration in the obstetric patient and the physiologic mechanisms involved. This article addresses whether the hypotensive effects attributed to the atrial natriuretic factor are the reason for the apparent failure of prehydration. METHODS: Atrial natriuretic factor was measured before (baseline) and 10 min after spinal anesthetic drug injection (control) in 48 healthy pregnant patients scheduled for elective cesarean section. Sixteen patients received hydration with 15 ml/kg crystalloid immediately before spinal anesthesia, 16 patients received the same volume starting with the spinal anesthetic injection, and the remaining 16 patients received no prehydration (control). Blood pressure, heart rate, ephedrine requirements, infused fluids, and urine output were measured. RESULTS: Atrial natriuretic factor concentrations increased significantly in prehydrated patients but not in the control group. There was a significant correlation in the change in atrial natriuretic factor concentrations and urine output but no correlation in the control atrial natriuretic factor concentrations and blood pressure or ephedrine requirements. Ephedrine requirements and blood pressure did not differ significantly among study groups. CONCLUSIONS: Atrial natriuretic factor is a potent endogenous diuretic in the pregnant patient but does not appear to be involved in short-term cardiovascular homeostasis after spinal anesthesia. Prehydration appears to prevent hypotension after spinal anesthesia in the obstetric patient.
PMID: 11506108, UI: 21396908
Anesthesiology 2001 Aug;95(2):334-9
Department of Emergency Medicine and Surgery, Groupe Hospitalier Pitie-Salpetriere, Universite Pierre et Marie Curie, Paris, France. valerie.safa@psl.ap-hop-paris.fr
BACKGROUND: Lumbar epidural blood patch (EBP) is a common treatment of post-dural puncture headache, but its effectiveness and mode of action remain a matter of debate. The aim of this study was to assess both the effectiveness and the predictive factors of failure of EBP on severe post-dural puncture headache. METHODS: This prospective observational study includes all patients treated in the authors' hospital with EBP for incapacitating post-dural puncture headache, from 1988 to 2000. The EBP effect was classified into complete relief (disappearance of all symptoms), incomplete relief of symptoms (clinically improved patients who recovered sufficiently to perform normal daily activity), and failure (persistence of severe symptoms). The following data were analyzed using a logistic regression to identify predictive factors of failure of EBP: (1) patient characteristics; (2) circumstances of dural puncture; (3) delay between dural puncture and EBP; and (4) the volume of blood injected for EBP. RESULTS: A total of 504 patients were analyzed. The frequency rates of complete relief, incomplete relief of symptoms, and failure after EBP were 75% (n = 377), 18% (n = 93), and 7% (n = 34), respectively. In a multivariate analysis, only the diameter of the needle used to perform dura mater puncture (odds ratio = 5.96; 95% confidence interval, 2.63-13.47; P < 0.001) and a delay in EBP less than 4 days (odds ratio = 2.63; 95% confidence interval, 1.06-6.51; P = 0.037) were independent significant risk factors for a failure of EBP. CONCLUSIONS: Epidural blood patch is an effective treatment of severe post-dural puncture headache. Its effectiveness is decreased if dura mater puncture is caused by a large bore needle.
PMID: 11506102, UI: 21396902
Pediatrics 2001 Jun;107(6):1494
PMID: 11403074, UI: 21292308
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