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Acta Anaesthesiol Scand 2003 May;47(5):630-4
Department of Neurology and Department of Anaesthesiology and Intensive Care Medicine, Haukeland University Hospital, Bergen, Norway.
[Medline record in process]
Myotonia congenita (MC) is caused by a defect in the skeletal muscle chloride channel function, which may cause sustained membrane depolarisation. We describe a previously healthy 32-year-old woman who developed a life-threatening muscle spasm and secondary ventilation difficulties following a preoperative injection of suxamethonium. The muscle spasms disappeared spontaneously and the surgery proceeded without further problems. When subsequently questioned, she reported minor symptoms suggesting a myotonic condition. Myotonia was found on clinical examination and EMG. The diagnosis MC was confirmed genetically. Neither the patient nor the anaesthetist were aware of the diagnosis before this potentially lethal complication occurred. We give a brief overview of ion channel disorders including malignant hyperthermia and their anaesthetic considerations.
PMID: 12699527, UI: 22585613
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Acta Anaesthesiol Scand 2003 May;47(5):604-9
Department of Anaesthesia, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
BACKGROUND: Ketamine efficacy as an analgesic adjuvant has been studied in several clinical settings with conflicting results. The aim of this study was to investigate the effect of ketamine on spontaneous and swallowing-evoked pain after tonsillectomy. METHODS: Fifty children were randomized to receive premedication with either ketamine 0.1 mg kg-1 i.m. or placebo given 20 min before induction of a standard general anaesthesia. All children received rectal diclofenac 2 mg kg-1 and fentanyl 1 micro g kg-1 i.v. before surgery. RESULTS: The ketamine group showed significantly lower pain scores both at rest and on swallowing, with less total paracetamol consumption (P < 0.05) during the 24 h after surgery. Significantly more patients required postoperative morphine titration in the control group (P < 0.05). The time to the first oral intake, and duration of i.v. hydration, were significantly shorter and the quality of oral intake was significantly better in the ketamine group (P < 0.05). There were no differences in the incidence of vomiting or dreaming between the groups. CONCLUSION: Premedication with a small dose of ketamine reduces swallowing-evoked pain after tonsillectomy in children who received an analgesic regimen combining an opioid and a NSAID.
PMID: 12699521, UI: 22585607
Acta Anaesthesiol Scand 2003 May;47(5):593-600
Departments of Anesthesiology and Clinical Neurophysiology, University Medical Center Nijmegen, HB, Nijmegen, the Netherlands.
BACKGROUND: There are at least three components of the anesthetic state: loss of consciousness, amnesia and obtundation of reflex responses to noxious stimuli. To investigate the third component, we used a standard electrical stimulus to evoke a blink reflex, which was electromyographically recorded. These data may give information on the anesthetic state. METHODS: The relation between the electrically evoked blink and corneal reflexes and the depth of sedation and anesthesia induced with intravenous midazolam was investigated. Ten patients received i.v. increments of midazolam (1 mg, 2 mg, 3 mg, 3 mg, 3 mg, etc., until a 21-mg total dose) to create a step-wise deepening of sedation and anesthesia. Depth of anesthesia was assessed by the Observer's Assessment of Alertness/Sedation (OAAS) scale, ranging from 5 ( = awake and alert) to 0 ( = no motor response to tetanic stimulation). RESULTS: Latency of the first (R1) and second (R2) blink components and the corneal (C) reflex component increased, whereas duration and area decreased with increasing depth of sedation and anesthesia. R1 was last seen at an OAAS score [mean (SD)] of 1.8 (0.8), R2 at a score of 3.1 (1.1), C at a score of 3.8 (0.8), and R3 at 4.8 (0.5). These end-points were all statistically different from each other, except R2 vs. C. CONCLUSIONS: Our results suggest that the differential sensitivity of the components of the blink reflex could be useful to monitor depth of sedation and light levels of anesthesia during the administration of midazolam.
PMID: 12699519, UI: 22585605
Acta Anaesthesiol Scand 2003 May;47(5):588-92
Department of Anaesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Department of Anaesthesiology, Yamanashi Medical University, Yamanashi, Department of Physiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
BACKGROUND: In anaesthetized patients, body temperature decreases often, but overweight patients become less hypothermic. Obesity in itself protects body heat, and thermoregulatory reflexes may maintain normothermia in obese patients. We tested the hypothesis that even slight obesity increases the vasoconstriction threshold. METHODS: Twenty male patients aged 30-65 years scheduled for open abdominal surgery were allocated to two groups: body fat >/=25% (obese group, n = 10), or <25% (normal weight group, n = 10). Anaesthesia was maintained with 0.4% isoflurane and opioid. The thermoregulatory vasoconstriction threshold was defined by the tympanic membrane temperature at which the skin temperature gradient equalled 0 degrees C. Plasma adrenaline, noradrenaline and leptin were measured. RESULTS: Age, height, heart rate and blood pressure did not differ between the two groups of patients. In the obese group the vasoconstriction threshold was higher than that in the normal weight group: 36.0 +/- 0.1 vs. 35.5 +/- 0.2 degrees C. Consequently, after 4 h of anaesthesia, the core temperature was highest in the obese patients: 36.4 +/- 0.1 vs. 35.5 +/- 0.2 degrees C. CONCLUSIONS: These results suggest that core temperature is maintained in obese patients because their vasoconstriction threshold to a low environmental temperature is high.
PMID: 12699518, UI: 22585604
Acta Anaesthesiol Scand 2003 May;47(5):576-82
Department of Anesthesia and Section for Lung Diseases and Allergy, Ullevaal University Hospital, Oslo, and 3Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway.
BACKGROUND: Muscle relaxants are believed to be responsible for 2/3 of the cases of anaphylactic reactions during anesthesia. This assumption is based mainly on positive skin tests obtained in individuals that have experienced anesthesia-related anaphylaxis. A positive skin test is supposed to be associated with mast cell degranulation of vasoactive amines. In the present study we tested the frequency of positive skin tests with two commonly used muscle relaxants, rocuronium and cisatracurium, in a selected group of volunteers with low potential for allergic reactions. METHODS: Thirty healthy volunteers without known allergy or previous exposure to muscle relaxants were studied. Low potential for allergic reactions was determined prior to inclusion in the study, using various allergy tests. Each individual was tested with intradermal and skin prick tests, and molar drug concentration thresholds for positive skin reactions were determined using a dilution titration technique. The presence or absence of mast cell degranulation was tested by electron microscopic investigation of skin biopsies obtained from positive and negative skin reactions. RESULTS: None of the volunteers had a positive skin prick test. More than 90% of the volunteers had a positive intradermal test with both rocuronium and cisatracurium. The highest molar drug concentration that was not associated with a positive intradermal test was 10-6 M (rocuronium) and 10-7 M (cisatracurium), equivalent to vial dilution 1 : 1000 for both drugs. In none of the volunteers was mast cell degranulation detected. CONCLUSION: Non-mast-cell-mediated positive intradermal skin reactions are frequently occurring with rocuronium and cisatracurium, even at vial dilution 1 : 1000. A clinically applicable test technique is needed that is able to separate positive skin tests associated with mast cell degranulation from non-mast-cell-mediated reactions.
PMID: 12699516, UI: 22585602
Acta Anaesthesiol Scand 2003 May;47(5):569-75
Departments of Anesthesia and Intensive Care and of Experimental Research, Lund University, Malmo University Hospital, Malmo, Department of Clinical Neurophysiology, Lund University Hospital, Lund, Sweden.
BACKGROUND: Little is known about the influence of racemic ketamine on autoregulation of cerebral blood flow (CBF), and available reports regarding its influence on cerebral hemodynamics are contradictory. This study was designed to evaluate cerebrovascular responses to changes in the mean arterial pressure (MAP) during ketamine anesthesia. METHODS: In eight normoventilated pigs anesthesia was induced with propofol and maintained by i.v. infusion of ketamine (15.0 mg kg-1.h-1) during measurements. The intra-arterial xenon clearance technique was used to calculate CBF. Balloon-tipped catheters were introduced in the inferior caval vein and mid-aorta, and increases or decreases by up to 40% in mean arterial pressure (MAP) in random order were achieved by titrated inflation of these balloon catheters. Cerebral blood flow was determined at each MAP level. Regression coefficients of linear pressure-flow curves were calculated in all animals. RESULTS: From the mean baseline level (101 mmHg) MAP was reduced by 20% and 40%, and increased by 26% and 43%. The maximal mean increase and decrease in MAP induced a 12% increase and a 15% decrease, respectively, of CBF from the mean baseline level (52.6 ml.100 g-1.min1). The 95% confidence interval (-0.02; 0.38) of the mean regression coefficient of individual pressure-flow curves does not include the regression coefficient (0.64) of a linear correlation between MAP and CBF including origo (correlation coefficient 0.99), which indicates complete lack of cerebrovascular autoregulation. CONCLUSIONS: We conclude that autoregulation of CBF is not abolished during continuous ketamine infusion in normoventilated pigs and that previous divergent conclusions are unlikely to be associated with severe impairment of cerebrovascular autoregulation.
PMID: 12699515, UI: 22585601
Acta Anaesthesiol Scand 2003 May;47(5):564-8
Department of Anaesthesiology and Intensive Care, Lund University Hospital, Lund, Sweden.
BACKGROUND: Artificial humidification of dry inspired gases seems to reduce the drop in body temperature during surgery. The aim of this study was to evaluate the humidity and temperature of anaesthetic gases with heat and moisture exchangers (HMEs). The secondary aim was to evaluate if HMEs in combination with low-flow anaesthesia could prevent a decrease in the body temperature during general anaesthesia. METHODS: Ninety patients scheduled for general surgery were randomised to receive a fresh gas flow of 1.0, 3.0 or 6.0 l min-1 with or without HMEs in a circle anaesthesia system. Relative humidity, absolute humidity, temperature of inspired gases and body temperatures were measured during 120 min of anaesthesia. RESULTS: The inspiratory absolute humidity levels with HMEs were 32.7 +/- 3.1, 32.1 +/- 1.1 and 29.2 +/- 1.9 mg H2O l-1 and 26.6 +/- 2.3, 22.6 +/- 3.0 and 13.0 +/- 2.6 mg H2O l-1 without HMEs after 120 min of anaesthesia with 1.0, 3.0, or 6.0 l min-1 fresh gas flows (P < 0.05, between with and without HME). The relative humidity levels with HMEs were 93.8 +/- 3.3, 92.7 +/- 2.2 and 90.7 +/- 3.5%, and without the HMEs 95.2 +/- 4.5, 86.8 +/- 8.0 and 52.8 +/- 9.8% (P < 0.05, between with and without HMEs in the 3.0 and 6.0 l min-1 groups). The inspiratory gas temperatures with HMEs were 32.5 +/- 2.0, 32.4 +/- 0.5 and 31.0 +/- 1.9 degrees C, and 28.4 +/- 1.5, 27.1 +/- 0.8 and 26.1 +/- 0.6 degrees C without HMEs after 120 min of anaesthesia (P < 0.05, between with and without HME). The tympanic membrane temperatures at 120 min of anaesthesia were 35.8 +/- 0.6, 35.5 +/- 0.6 and 35.4 +/- 0.8 degrees C in the groups with HMEs, and 35.8 +/- 0.6, 35.3 +/- 0.7 and 35.3 +/- 0.9 degrees C in the groups without the HMEs (NS). CONCLUSIONS: The HMEs improved the inspiratory absolute humidity, relative humidity and temperature of the anaesthetic gases during different fresh gas flows. However, the HMEs were not able to prevent a body temperature drop during low-flow anaesthesia.
PMID: 12699514, UI: 22585600
Acta Anaesthesiol Scand 2003 May;47(5):541-8
Department of Cardiothoracic Anesthesia and Intensive Care, Sahlgrenska University Hospital, Goteborg, Department of Anesthesia and Intensive Care, Umea University Hospital, Umea, Sweden.
BACKGROUND: Assessment of preload independent left ventricular function with conductance volumetry is traditionally accomplished by inflating a balloon in the inferior caval vein. Our aim was to investigate if a similar change in preload could be achieved by positive pressure ventilation with large tidal volume. METHODS: Conductance volumetry generating left ventricular pressure-volume loops was used in seven pentobarbital-anesthetized pigs. Changes in preload recruitable stroke work were studied, comparing the effects of inferior vena cava occlusion (IVCO) or large tidal volume (LTV). Cardiodepression was induced by halothane anesthesia and halothane + phenylephrine, and stimulation by epinephrine infusion. RESULTS: Although the decreasis in left ventricular end diastolic volume was slightly less with LTV (16.5 +/- 1.7 ml, mean +/- SEM) than with IVCO (22.4 +/- 1.7 ml) (P < 0.0001) the PRSW-slopes showed a high degree of correlation (r=0.80, P < 0.0001). Although peak tracheal pressures increased significantly to 27.8 +/- 0.9 mmHg during LTV, esophageal pressures (used as an indicator of pericardial pressure) were unchanged. CONCLUSIONS: Positive pressure ventilation with LTV is similar to IVCO in creating transient changes in preload, necessary for assessment of left ventricular systolic function. This observation was valid also during drug-induced cardiac depression and stimulation. The preload recruitable stroke work used for this validation was shown to be a reliable and stable method.
PMID: 12699510, UI: 22585596
Acta Anaesthesiol Scand 2003 May;47(5):532-40
Departments of Anaesthesiology and Intensive Care and Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden, Centre for Neuroscience, National Sun Yat-sen University, Kaohsiung, Taiwan.
BACKGROUND: General anaesthesia may stimulate the renin-angiotensin system. Exogenous administration of angiotensin II elevates blood pressure mainly via increased total peripheral resistance caused by direct vasoconstrictor actions. It is also well established that the hypertensive effect of angiotensin II involves a cerebrally mediated component. The hypertensive effect of an intravascular infusion of angiotensin II is substantially reduced by isoflurane anaesthesia. A likely mechanism is that isoflurane anaesthesia reduces the cerebral component of the angiotensin II effect on blood pressure, which involves influences on autonomic nervous activity. In an experimental study in sheep we used real-time spectral analysis of arterial blood pressure signals to obtain information on parasympathetic, respectively, sympathetic autonomic nervous activity in response to angiotensin II administration during isoflurane anaesthesia. METHODS: The study was performed on conscious and isoflurane-anaesthetized sheep that were subjected to an intracarotid infusion of angiotensin II (85 ng kg-1 min-1) during 20 min followed by a recovery period of 30 min and thereafter an injection of the angiotensin II, AT1-receptor antagonist losartan (10 mg kg-1) i.v. Systemic and regional (renal and femoral) circulation was monitored in parallel to real-time spectral analysis of the arterial blood pressure signal. RESULTS: Isoflurane anaesthesia reduced both magnitude and duration of the hypertensive response to angiotensin II infusion. The power spectral density in the frequency band that represents sympathetic activation, correlated to the changes in mean arterial pressure in conscious animals, but not during isoflurane anaesthesia. CONCLUSION: We conclude that the cerebrally mediated component of the hypertensive effect of circulating angiotensin II is largely eliminated by isoflurane anaesthesia. Spectral power analysis of the blood pressure signal indicates that the cerebral angiotensin II effect involves activation of sympathetic nervous activity.
PMID: 12699509, UI: 22585595
Acta Anaesthesiol Scand 2003 Apr;47(4):496
Address:Dr Martin Johr and Kurt SperlInstitut fur Anasthesie, KantonsspitalCH-6000 Luzern 16Switzerlande-mail: joehrmartin@bluewin.ch
PMID: 12694161, UI: 22580160
Acta Anaesthesiol Scand 2003 Apr;47(4):482-4
Klinik fuer Anesthesiologie und Intensivtherapie, Friedrich-Schiller-Universitaet Jena, Germany, Department of Kinesiology, University of Wisconsin, WI.
BACKGROUND: Myoclonic movements are a common problem during the induction of general anesthesia with etomidate. We investigated the influence of pretreatment with the opioid sufentanil on the incidence of etomidate-induced myoclonus. METHODS: Forty female patients (ASA physical status I-III) were randomly assigned to receive double-blinded either 0.3 micro g kg-1 of sufentanil or placebo 150 s before the induction of sleep with 0.3 mg kg-1 of etomidate. The patients were observed for any myoclonic movement. Grade of dizziness, breathing frequency, non-invasive blood pressure and heart rate were measured during the study period. RESULTS: None of the 20 patients receiving sufentanil had myoclonic movements after the administration of etomidate, whereas 16 patients in the placebo group (80%) experienced such movements (P<0.01). No cases of apnoea before induction of sleep were seen in the sufentanil group. CONCLUSION: Sufentanil 0.3 micro g kg-1 is an effective and safe drug to reduce myoclonus after etomidate without causing any harmful side-effect.
PMID: 12694150, UI: 22580149
Acta Anaesthesiol Scand 2003 Apr;47(4):475-81
Department of Pediatrics, College of Medicine, Hanyang University and Department of Anesthesiology, College of Medicine, Seoul National University, Seoul, Korea.
BACKGROUND: We tried to determine whether the severity of additional mean arterial pressure (MAP) elevation after endotracheal intubation during general anesthesia could be predicted with preanesthetic recurrence quantification analysis of heart rates in hypertensive and normotensive patients. METHODS: Twenty-four newly diagnosed hypertensive patients and 34 normotensive patients were included. We defined DeltaMAP = maximal mean MAP after endotracheal intubation - average MAP before general anesthesia. We classified each of the hypertensive and normotensive patients into mild (DeltaMAP </= 35 mmHg [median value of DeltaMAP in the hypertensive patients]) and severe group (DeltaMAP > 35 mmHg). Using preanesthetic RR interval data, we calculated classical linear and non-linear indices of RR interval dynamics, and performed recurrence quantification analysis to calculate three preanesthetic recurrence indices, percentage of recurrence (%REC), percentage of determinism (%DET), and maximal length of recurrence (Lmax). RESULTS: In the hypertensive patients, all preanesthetic classical indices showed no significant difference between the mild and severe group and showed no significant linear correlation with the DeltaMAP. However, the Lmax was significantly higher in the severe than in the mild group (16.10 +/- 3.79 vs. 7.90 +/- 0.73, P < 0.005) and, moreover, linearly correlated with the DeltaMAP (r = 0.671, P = 0.001). In the normotensive patients, all preanesthetic classical and recurrence indices showed no significant difference between the two groups. CONCLUSION: In hypertensive patients, the severity of additional MAP elevation after tracheal intubation during general anesthesia can be predicted by the preanesthetic recurrence quantification analysis of heart rates.
PMID: 12694149, UI: 22580148
Acta Anaesthesiol Scand 2003 Apr;47(4):466-71
Department of Anesthesiology, Shanghai First People's Hospital, Shanghai, China.
BACKGROUND: The rapidly extracted auditory evoked potentials index (A-lineTM ARX Index or AAI) has been proposed as a method to measure the depth of anesthesia. A prospective study was designed to assess the performance of AAI to detect the recovery and loss of wakefulness in anesthetized and paralyzed patients. METHODS: Fourteen adult patients undergoing elective surgery were anesthetized with propofol 1.5 mg kg-1, vecuronium 0.1 mg kg-1 and further propofol 1.0 mg kg-1. Wakefulness was measured by the ability of the patient to respond to command using the isolated forearm technique (IFT). After the patient responded, propofol was infused at 10 mg kg-1. h-1 until wakefulness (responsiveness) was lost. The AAI was recorded continuously throughout the study and analyzed off-line. RESULTS: The AAI showed a significant difference between the values registered during, 30 s before and 30 s after the recovery, and also between 30 s before and 30 s after the loss of wakefulness. The prediction probability (Pk) values for AAI were 0.786 and 0.864 during the transitions from unresponsiveness to responsiveness and from responsiveness to unresponsiveness. The area under the receiver operating characteristic curve for the responsive and unresponsive values was 0.926 (SE 0.002, 95% CI 0.922-0.931), and the AAI values of approximately 5%, 50% and 95% predicted probability of wakefulness were 19, 29 and 39, respectively. CONCLUSION: The AAI may be a good predictor of recovery and loss of wakefulness for anesthetized and paralyzed patients.
PMID: 12694147, UI: 22580146
Acta Anaesthesiol Scand 2003 Apr;47(4):433-8
Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland.
BACKGROUND: Pain becomes chronic in 22-67% of patients who undergo a thoracotomy. Thoracic epidural analgesia (TEA) has replaced less invasive methods to manage postoperative pain. We wanted to find out if active use of TEA, combined with extended pain management at home, reduces the incidence of chronic post-thoracotomy pain. METHODS: All consecutive thoracotomy patients during a 16-month period were included. On the ward, pain was measured daily by VAS during rest and coughing and the consumption of analgesics was registered. The patients were interviewed one week after discharge by telephone and by a questionnaire after 3 and 6 months to find out how much pain they had. RESULTS: A total of 114 patients were recruited. The data were analysed from 89 patients who had had TEA and 22 who had had other methods. TEA was effective in alleviating pain at rest and during coughing. In the TEA patients the incidence of chronic pain of at least moderate severity was 11% and 12% at 3 and 6 months, respectively. One week after discharge 92% of all patients needed daily pain medication. CONCLUSIONS: TEA seems effective in controlling evoked postoperative pain, but technical problems occurred in 24% of the epidural catheters. The incidence of chronic pain was lower compared with previous studies where TEA was not used. The patients had significant pain and needed regular pain medication and instructions during the first week after discharge. Extended postoperative analgesia up to the first week at home is warranted.
PMID: 12694143, UI: 22580142
Acta Anaesthesiol Scand 2003 Apr;47(4):419-24
Department of Anesthesiology and Reanimatology, Gunma University, School of Medicine and Department of Anesthesiology, Keiyu Orthopedic Hospital, Gunma, Japan.
BACKGROUND: There have been many studies regarding the etiology of postoperative cognitive dysfunction after coronary artery bypass graft (CABG) surgery. Although its etiology remains unresolved, one possible factor related to postoperative cognitive dysfunction is a reduced internal jugular venous oxygen hemoglobin saturation (SjvO2) during the rewarming period. The purpose of this study was to examine the effect of rewarming rates on SjvO2 during rewarming. METHODS: One-hundred patients scheduled for elective CABG surgery were randomly divided into two groups; control group (0.48 +/- 0.09 degrees C, n = 50), slow rewarming group (0.24 +/- 0.09 degrees C, n = 50). After the induction of anesthesia, a fiberoptic oximetry oxygen saturation catheter was inserted into the right jugular bulb to monitor SjvO2 continuously. Hemodynamic parameters, arterial and jugular venous blood gases were measured at nine time-points. RESULTS: Cerebral desaturation (defined as a SjvO2 value below 50%) during rewarming was more frequent in the control group than in the slow group. Cerebral desaturation time (duration when SjvO2 was less than 50%) and the ratio of the cerebral desaturation time to the total CPB time in the control group differed significantly from those in the slow group (control group: 17 +/- 11 min, 12 +/- 4%, slow group: 10 +/- 8 min, 7 +/- 4%, respectively, P < 0.05). There was no significant difference in mini-mental state examination on the day before the operation nor at 1 month after the surgery among four values (the day before the operation: control group; 48 +/- 8, slow group; 48 +/- 7, at one month after the surgery: control group; 46 +/- 7, slow group; 45 +/- 9). CONCLUSIONS: A slow rewarming rate could reduce the chance of a decrease in SjvO2 during rewarming.
PMID: 12694140, UI: 22580139
Acta Anaesthesiol Scand 2003 Apr;47(4):411-5
Department of Anesthesia and Critical Care, Instituto Nacional de Ciencias Medicas y Nutricion, 'Salvador Subiran', Mexico City, Mexico.
BACKGROUND: The techniques, drugs and depth of sedation for flexible fiberoptic bronchoscopy is controversial, and several reports consider that the routine use of sedation is not a prerequisite. We evaluate whether the addition of sedation with propofol improves patient tolerance, compared to local anesthesic of the airway only. METHODS: Eighteen patients with pneumonia undergoing flexible fiberoptic bronchoscopy were included in a randomized, single blind, prospective controlled study. The non-sedation group received airway topical anesthesia, whereas the sedation group received topical anesthesia and intravenous sedation with propofol. The degree of pain, cough, sensation of asphyxiation, degree of amnesia, global tolerance and acceptance of another bronchoscopy in the future were noted. Changes in blood pressure, heart rate and saturation of oxygen by pulse oximetry were also evaluated. RESULTS: The patients in sedation group had less cough (P < 0.05), pain (P < 0.01) and sensation of asphyxiation (P < 0.001). Global tolerance to the procedure was significantly better in the group under sedation (P < 0.01). These patients had total amnesia to the procedure (P < 0.0001), thus is more probable that will accept another bronchoscopy in the future (P < 0.01). There was a significant rise in heart rate and blood pressure in the patients without sedation. There were no differences in oxygen saturation (P = 0.75). CONCLUSIONS: Our results show that if we administer propofol for sedation, in addition to local anesthesia of the airway, the tolerance to the procedure is much better. Also it appears that sedation with propofol is safe if we carefully select and monitor the patient.
PMID: 12694138, UI: 22580137
Acta Anaesthesiol Scand 2003 Apr;47(4):378-82
Department of Anaesthesia, Torrecardenas Hospital, Almeria, Spain.
BACKGROUND: The evaluation of the international distribution in biomedicine research is a subject that creates expectations. This study assesses the recent evolution of world-wide distribution of research in the anaesthesiology field and discusses some of the possible factors which could give rise to changes in the interpretation of absolute results. METHODS: A search on Medline was run to obtain the source country of the journal articles (with abstract) from 10 important anaesthesia journals in the 1997-2001 period. The data were analysed and standardized to journal impact factor values of each publication and population size. Annual evolution in the number of publications in the countries with the largest scientific production was analysed. Furthermore, the distribution of articles by country of origin was studied for each journal. RESULTS: The 9724 publications came from 65 countries. In absolute numbers, the USA leads research in anaesthesiology (24.4%). The evaluation of the contribution of the more productive countries revealed a progressive increase in the German contribution (from 5.1% to 9.4%) and a decrease in the American contribution (from 28.6% to 21.8%) over the 5 years analysed. In relative terms, Finland, Sweden and Denmark were the most productive countries per million inhabitants (8.8, 7.2 and 6 publications/year, respectively). CONCLUSION: The geographic distribution of the publications on anaesthesiology must not only be analysed in absolute numbers, where the USA is the most productive. The North-European countries show the largest production/number of inhabitants ratio; whereas the largest percentage increase during the period is found in Germany.
PMID: 12694133, UI: 22580132
Anaesthesia 2003 May;58(5):508-9
Department of Anaesthesia, Norfolk and Norwich University NHS Trust, Norfolk, UK.
PMID: 12694040, UI: 22580343
Anaesthesia 2003 May;58(5):508
Anaesthetic Dept, Royal United Hospital, Combe Park, Bath, UK Anaesthetic Dept, Kansai Medical University, Moriguchi City, Osaka 570-8507, Japan.
PMID: 12694039, UI: 22580342
Anaesthesia 2003 May;58(5):505
Department of Anaesthesia, Worcester Royal Hospital, Worcester, WR5 1DD, UK.
PMID: 12694035, UI: 22580338
Anaesthesia 2003 May;58(5):504-5
Department of Anaesthesia, Central Manchester and Manchester Children's University Hospitals, Manchester, UK.
PMID: 12694034, UI: 22580337
Anaesthesia 2003 May;58(5):503-4
Department of Ophthalmology, Worcestershire Royal Hospital, Worcester WR5 1DD, UK.
PMID: 12694033, UI: 22580336
Anaesthesia 2003 May;58(5):502-3
Department of Anaesthesia, Kettering General Hospital, Rothwell Road, Kettering, Northamptonshire NN16 8UZ, UK.
PMID: 12694031, UI: 22580334
Anaesthesia 2003 May;58(5):501
Kettering General Hospital, Kettering NN16 8UZ, UK E-mail: gmuralikrishna@hotmail.com
PMID: 12694030, UI: 22580333
Anaesthesia 2003 May;58(5):499-500
Royal Infirmary, Edinburgh EH16 4SA, UK E-mail: mckenzie_alistair@hotmail.com
PMID: 12694028, UI: 22580331
Anaesthesia 2003 May;58(5):497-8
City Hospital, Ankara 06100, Turkey E-mail: didemdal@yahoo.com
PMID: 12694025, UI: 22580328
Anaesthesia 2003 May;58(5):482
Southampton General Hospital, Southampton, SO16 6YD, UK E-mail: rajdhamrait@hotmail.com
PMID: 12694008, UI: 22580311
Anaesthesia 2003 May;58(5):480
Copenhagen University Hospital, H:S Rigshospitalet, DK-2100 Copenhagen, Denmark E-mail: viby@rh.dk
PMID: 12694006, UI: 22580309
Anaesthesia 2003 May;58(5):466-70
Specialist Registrar in Anaesthesia, Consultant Endocrinologist, Consultant Urologist and Consultant Anaesthetist, The Ipswich Hospital, Heath Road, Ipswich IP4 5 PD, UK.
We report on the anaesthetic management of a 28-year-old woman presenting for excision of a reninoma. This is a very rare tumour of the juxtaglomerular cells of the kidney, which can be cured immediately by surgery. Previous reports have failed to record the presence or absence of peri-operative cardiovascular lability. We have shown that blood pressure, cardiac index (CI) and systemic vascular resistance (SVRI) were remarkably stable in our patient throughout surgery, even during manipulation of the tumour. Isolation of the tumour was associated with a 23% reduction in SVRI, and a similar decrease in blood pressure. The cardiovascular lability associated with the removal of catecholamine-secreting tumours was not seen in this case.
PMID: 12694004, UI: 22580307
Anaesthesia 2003 May;58(5):437-43
Special Registrar in Anaesthesia, St George's Hospital, London, UK Consultant Anaesthetist, Kingston Hospital, Galsworthy Road, Kingston-upon-Thames KT2 7QB, UK.
The provision of anaesthesia for patients suffering from anorexia nervosa or bulimia nervosa is not without its risks. The anaesthetist needs to appreciate that these eating disorders can predispose the patient to significant risk of multi-organ dysfunction related to starvation and purging. Any such organ dysfunction can have serious implications on morbidity and mortality. Therefore, careful peri-operative management is essential to avoid anaesthetic complications. Both disorders are common, with incidences in the general population of up to 30% in girls and young women. A review of the literature on the provision of anaesthesia for anorexic patients was carried out to evaluate the potential impact of these disorders on the patient's physiology and the subsequent implications for anaesthesia.
PMID: 12693999, UI: 22580302
Anaesthesia 2003 May;58(5):428-431
Consultant, Department of Anaesthesia, Walsgarave Hospital, Coventry, UK Consultant, Department of Anaesthesia, Royal Gwent Hospital, Newport, UK Consultant, Department of Anaesthesia, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN, UK.
[Record supplied by publisher]
Eighty-seven pregnant mothers undergoing elective Caesarean section were randomly allocated either to the full left lateral position (n = 45) or to the supine position with 12 degrees left lateral tilt (n = 42) after a combined spinal-epidural (CSE) in the sitting position and an initial 2 min in the full right lateral position. Fewer mothers were hypotensive while in the study position [29 (64%) in lateral group vs. 38 (90%) in the tilted supine group; p = 0.03]. Mothers in the lateral group tended to become hypotensive after turning them back to the tilted supine position immediately before surgery; hence the number of mothers who were hypotensive from the insertion of the CSE until delivery were similar [36 (80%) vs. 38 (90%)]. Mothers in the lateral group needed a lower dose of ephedrine to treat their hypotension while in their study position {median (interquartile range [range]) 6 (0-12 [0-36]) mg vs. 12 (6-18 [0-36]) mg, respectively; p = 0.04} but ephedrine requirements were similar overall {12 (6-12 [0-36]) mg vs. 12 (6-18 [0-36]) mg}, respectively. The full left lateral position reduces the incidence of early hypotension compared with the tilted supine position with tilt, and makes it easier to treat.
PMID: 12693997
Anaesthesia 2003 May;58(5):412-421
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9 PL, UK Department of Anaesthesia, Wirral NHS Trust, UK Department of Anaesthesia, Central Manchester and Manchester Children's University Hospitals NHS Trust, Manchester, UK School of Epidemiology and Health Sciences, University of Manchester, Manchester, UK School of Nursing, Midwifery & Health Visiting, University of Manchester, Manchester, UK Health Economics Research at Manchester, University of Manchester, Manchester, UK.
We compared the cost-effectiveness of general anaesthetic agents in adult and paediatric day surgery populations. We randomly assigned 1063 adult and 322 paediatric elective patients to one of four (adult) or two (paediatric) anaesthesia groups. Total costs were calculated from individual patient resource use to 7 days post discharge. Incremental cost-effectiveness ratios were expressed as cost per episode of postoperative nausea and vomiting (PONV) avoided. In adults, variable secondary care costs were higher for propofol induction and propofol maintenance (propofol/propofol; p < 0.01) than other groups and lower in propofol induction and isoflurane maintenance (propofol/isoflurane; p < 0.01). In both studies, predischarge PONV was higher if sevoflurane/sevoflurane (p < 0.01) was used compared with use of propofol for induction. In both studies, there was no difference in postdischarge outcomes at Day 7. Sevoflurane/sevoflurane was more costly with higher PONV rates in both studies. In adults, the cost per extra episode of PONV avoided was pound 296 (propofol/propofol vs. propofol/ sevoflurane) and pound 333 (propofol/sevoflurane vs. propofol/isoflurane).
PMID: 12693995
Anesthesiology 2003 Apr;98 Suppl 1:1-77
Publication Types:
PMID: 12701619, UI: 22587184
Other Formats: Links:
BMJ 2003 Apr 19;326(7394):863-4
Department of Anaesthesia, Royal Lancaster Infirmary, Lancaster LA1 4RP.
PMID: 12702623, UI: 22588087
Br J Anaesth 2003 May;90(5):707-8
Rome, Italy.
PMID: 12697609, UI: 22583274
Br J Anaesth 2003 May;90(5):689-91
Department of Anaesthesia, Saiseikai Shimonoseki General Hospital, Shimonoseki, Japan. Department of Anaesthesia, University of Yamanashi, Faculty of Medicine, Tamaho, Yamanashi 409-3898, Japan.
BACKGROUND: Even mild perioperative hypothermia is associated with several severe adverse effects. Resistive heating has possible advantages compared with other active warming systems because it can heat several fields independently. To assess this new warming system, we measured core temperature in patients during surgery who were warmed with circulating water mattresses, forced air covers or resistive heating covers. METHODS: Twenty-four patients undergoing laparoscopic cholecystectomy were randomly assigned to (i) circulating water mattress (38 degrees C), (ii) forced air warming (set to 'medium') or (iii) carbon-fibre resistive warming (38 degrees C). Warming was applied throughout anaesthesia and surgery. The groups were compared using one-way ANOVA and Student-Newman-Keuls tests. RESULTS: Confounding factors were similar among the groups. Core temperatures in each group decreased for 20 min, but subsequently increased in the forced air and resistive heating groups. There was no significant difference between the forced air and resistive heating groups at any time. In contrast, core temperature in the circulating water group continued to decrease. Consequently, core temperature in the circulating water group was significantly lower than in the other groups 30 min after anaesthetic induction and at later times. CONCLUSIONS: Resistive heating maintains core body temperature as well as forced air heating and both are better than circulating water. Resistive heating offers the advantage of adjustable heating pods. Br J Anaesth 2003; 90: 689-91
PMID: 12697600, UI: 22583265
Br J Anaesth 2003 May;90(5):686-8
Department of Anaesthesia and Intensive Care, Central Hospital, SE-721 89 Vasteras, Sweden.
BACKGROUND: The role of nitrous oxide in modern anaesthesia is questioned. The routine use of nitrous oxide was almost completely stopped in our department after November 1, 2000, and we now report some consequences. METHODS: Staff completed a questionnaire after 6 months, and we analysed the use of hypnotics and opioids after 12 months. The cost of drugs for the year after stopping nitrous oxide was compared with the cost 2 yr before. RESULTS: Less than half of the 55 staff members who answered the questionnaire used nitrous oxide in the 6 months after the stop, and they did so on only a few occasions. Half of the staff members thought the benefit of nitrous oxide was small. Most supported the change. The use of opioids was stable during the study period, and there was an annual increase of 12-14% in the use of hypnotics during the 3 yr. CONCLUSIONS: The staff questionnaire showed a strong acceptance of the new policy, and the use of other anaesthetic agents did not increase as expected. Has the value of nitrous oxide been overestimated? Br J Anaesth 2003; 90: 686-8
PMID: 12697599, UI: 22583264
Br J Anaesth 2003 May;90(5):665-70
University Department of Anaesthesia, Critical Care and Pain Management, Leicester University, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester LE5 4PW, UK. The Mater Misericordiae Hospital, Dublin 7, Republic of Ireland.
BACKGROUND: Low-dose intrathecal (spinal) morphine (0.1-0.2 mg) for Caesarean section delivers excellent postoperative analgesia but is associated with significant nausea and vomiting. We compared the antiemetic efficacy of cyclizine, dexamethasone, and placebo in this clinical setting. METHODS: Ninety-nine women undergoing elective Caesarean section under spinal anaesthesia were allocated randomly, in a double-blind study design, to receive either cyclizine 50 mg, dexamethasone 8 mg, or placebo as a single-dose infusion in saline 0.9%, 100 ml on completion of surgery. Spinal anaesthesia consisted of: hyperbaric bupivacaine 0.5%, 2.0 ml; fentanyl 10 micro g; and spinal morphine 0.2 mg. The primary outcome measure was the incidence of nausea. RESULTS: The incidence of nausea was significantly less in patients receiving cyclizine compared with dexamethasone and placebo (33 vs 60 and 67%, respectively, P<0.05). Severity of nausea and number of vomiting episodes were also less at 3-6 h in cyclizine patients. Overall satisfaction with postoperative care at 24 h, expressed on a 100 mm visual analogue scale, was greater in cyclizine [78 (28)] than either dexamethasone [58 (31), P=0.03] or placebo [51 (28), P=0.008]. CONCLUSION: We conclude that following spinal morphine 0.2 mg and fentanyl 10 micro g analgesia for Caesarean section, cyclizine 50 mg i.v. reduces the incidence of nausea compared with dexamethasone 8 mg i.v. or placebo. It also lessens the severity of nausea and vomiting, and increases maternal satisfaction in the early postoperative period. Br J Anaesth 2003; 90: 665-70
PMID: 12697596, UI: 22583261
Br J Anaesth 2003 May;90(5):659-64
Department of Anaesthesiology and Intensive Care and Department of Obstetrics and Gynaecology, Faculty of Medicine, Selcuk University, Konya, Turkey.
BACKGROUND: This study was designed to evaluate the effects of intrathecal isobaric bupivacaine 0.5% plus morphine and isobaric ropivacaine 0.5% plus morphine combinations in women undergoing Caesarean deliveries. METHOD: Twenty-five parturients received ropivacaine 15 mg and morphine 150 micro g (RM group) and twenty-five parturients received bupivacaine 15 mg and morphine 150 micro g (BM group) for spinal anaesthesia. Sensory and motor block, haemodynamics, postoperative analgesia, fetal outcomes, and side-effects were evaluated. RESULTS: Intrathecal bupivacaine-morphine and ropivacaine-morphine provided effective sensory anaesthesia and motor block. Time to reach complete motor block was shorter and time to complete recovery from motor block was longer in the BM group than the RM group (P<0.05). The time to regression of two dermatomes and time for the block to recede to the S2 dermatome were similar in both groups (P>0.05). Time to first complaint of pain and the mean total consumption of tenoxicam were similar in both groups (P>0.05). APGAR scores at 1 and 5 min were similar in the two groups, as were mean umbilical blood pH values (P>0.05). Hypotension and pruritus were the most common side-effects in both groups during the operation. CONCLUSION: Intrathecal isobaric ropivacaine 0.5% 15 mg plus morphine 150 micro g provides sufficient anaesthesia for Caesarean delivery. The ropivacaine-morphine combination resulted in shorter motor block, similar sensory and postoperative analgesia. Br J Anaesth 2003; 90: 659-64
PMID: 12697595, UI: 22583260
Br J Anaesth 2003 May;90(5):653-8
Department of Anesthesia, British Columbia Women's Hospital, Vancouver, British Columbia, Canada Present address: Nuffield Department of Anaesthetics, Oxford Radcliffe Hospitals, Oxford OX3 9DU, UK.
BACKGROUND: Dextromethorphan is an N-methyl-D-aspartic acid antagonist which can attenuate acute pain with few side-effects. In this prospective, randomized, double-blind study of dextromethorphan and intrathecal morphine, we investigated postoperative pain, pruritus, nausea and vomiting in women undergoing Caesarean section under spinal anaesthesia. METHODS: Women were allocated randomly to one of six groups, to receive intrathecal morphine 0.05, 0.1 or 0.2 mg plus oral dextromethorphan 60 mg or placebo. RESULTS: The addition of dextromethorphan did not reduce postoperative pain scores (P=0.83). Compared with women receiving intrathecal morphine 0.05 mg, women receiving higher doses had a significantly higher incidence of nausea and vomiting [odds ratio for intrathecal morphine 0.1 mg, 4.0 (95% confidence interval 1.2-14.1); for intrathecal morphine 0.2 mg, 7.9 (2.3-27.1)]. Compared with women receiving intrathecal morphine 0.05 mg, women receiving higher doses also had a significantly higher incidence of pruritus [odds ratio for intrathecal morphine 0.1 mg, 3.2 (95% confidence interval 1.3-8.2); for intrathecal morphine 0.2 mg, 3.7 (1.4-9.5)]. Women receiving dextromethorphan had a lower incidence of nausea and vomiting [odds ratio 2.6 (1.1-6.3)]. CONCLUSIONS: Postoperative pain after Caesarean section under spinal anaesthesia was not reduced by the addition of oral dextromethorphan to a multimodal approach including intrathecal morphine. Br J Anaesth 2003; 90: 653-8
PMID: 12697594, UI: 22583259
Br J Anaesth 2003 May;90(5):636-41
Department of Anesthesiology, Department of Pediatrics and Department of Neurological Surgery, University of Washington, Seattle, WA 98104, USA.
INTRODUCTION: Little is known about cerebral autoregulation in children. The aim of this study was to examine cerebral autoregulation in children. METHODS: Cerebral autoregulation testing was performed during less than 1 MAC sevoflurane anaesthesia in children (from 6 months to 14 yr) and in adults (18-41 yr). Mean middle cerebral artery flow velocities (V(MCA)) were measured using transcranial Doppler ultrasonography. Mean arterial pressure (MAP) was increased to whichever was greater: 20% above baseline or (i) 80 mm Hg for less than 9 yr, (ii) 90 mm Hg for 9-14 yr, and (iii) 100 mm Hg for adults. Cerebral autoregulation was considered intact if the autoregulatory index was >/=0.4. RESULTS: There were 13 subjects less than 2 yr old (Group 1), 13 subjects 2-5 yr (Group II), 14 subjects 6-9 yr (Group III), 12 subjects 10-14 yr (Group IV), and 12 adults (Group V; control group). All subjects had an autoregulatory index >/=0.4. There was no difference in autoregulatory index between children in Groups I-IV or between children and adults. DISCUSSION: We found no age-related differences in autoregulatory capacity during low-dose sevoflurane anaesthesia. We report no differences in autoregulatory capacity between children and adults. Br J Anaesth 2003; 90: 636-41
PMID: 12697592, UI: 22583257
Br J Anaesth 2003 May;90(5):630-5
Department of Anaesthesiology and Intensive Care, Catholic University of Sacred Heart, Rome, Italy.
BACKGROUND: Some studies support the view that meaningful auditory input can be processed by the brain during apparent surgical anaesthesia. Consequently, patients may be able to remember some information implicitly after anaesthesia as well through a 'dream-like process' (subconscious awareness). The aim of this study was to investigate the presence of subconscious awareness during anaesthesia and to examine its relationship to the mid-latency auditory evoked responses (MLAERs). METHODS: We studied 40 patients, ASA I-II, undergoing laparoscopic cholecystectomy. General anaesthesia was induced with thiopental 5 mg kg(-1), fentanyl 3 micro g kg(-1), and vecuronium 0.08 mg kg(-1). For the maintenance of anaesthesia, patients were randomly assigned to one of four anaesthetic regimen groups: sevoflurane+air in oxygen 40%; sevoflurane+nitrous oxide 60%; isoflurane+air in oxygen 40%; and isoflurane+nitrous oxide 60%. MLAERs were recorded before anaesthesia, at 1 MAC of inhaled anaesthetic and then 30 min after awakening. An audiotape with one of four stories was played immediately after intraoperative MLAER recording. Explicit and implicit memory was assessed 24 h after awakening. RESULTS: None of the patients had explicit recall. One of the patients from the isoflurane-air group showed implicit memory of listening to the audiotape. A dream-like process, in which they remembered implicitly the story played during anaesthesia, occurred in one of the patients from the sevoflurane-nitrous oxide group. In the patients with subconscious awareness, MLAERs were similar to that of the awake state with a Pa latency increase of less than 8.87. When there was a marked increase in Pa latency during anaesthesia, no subconscious awareness was observed. No statistically significant differences were found between Pa latency before and after anaesthesia. CONCLUSIONS: MLAERs may help to predict subconscious cerebral processing of auditory inputs during anaesthesia. Br J Anaesth 2003; 90: 630-5
PMID: 12697591, UI: 22583256
Br J Anaesth 2003 May;90(5):623-9
University of Glasgow Department of Anaesthesia, Glasgow Royal Infirmary, Glasgow G31 2ER, UK. Department of Anaesthesiology, University of Ulm, Steinhoevelstrasse 9, D-89075 Ulm, Germany.
BACKGROUND: General anaesthesia is a balance between hypnosis and analgesia. We investigated whether an increase in remifentanil blood concentration would reduce the amount of propofol required to maintain a comparable level of anaesthesia in 60 patients undergoing ambulatory surgery. METHODS: Patients were allocated randomly to receive remifentanil to a target blood concentration of 2 ng ml(-1) (low), 4 ng ml(-1) (medium), or 8 ng ml(-1) (high), administered by target-controlled infusion (TCI). After equilibration, propofol TCI was commenced in closed-loop control, with auditory evoked potentials (AEPex) as the input signal, aiming for an AEPex of 35. This was to ensure a comparable and unbiased level of anaesthesia in all patients. RESULTS: We found a dose-dependent decrease in propofol requirements with increasing remifentanil concentrations. The mean (95% CI) propofol target blood concentration during adequate anaesthesia was 4.96 (3.85-6.01) micro g ml(-1) in the low, 3.46 (2.96-3.96) micro g ml(-1) in the medium, and 3.01 (2.20-3.38) micro g ml(-1) in the high group. There was no significant difference when recovery end points were achieved between the groups. Cardiovascular changes were moderate, but most pronounced in the high concentration group, with a decrease in heart rate of 21% compared with baseline. The mean calculated effect site propofol concentration at loss of consciousness was 2.08 (1.85-2.32) micro g ml(-1), and at recovery of consciousness was 1.85 (1.68-2.00) micro g ml(-1). CONCLUSIONS: This study confirms a synergistic interaction between remifentanil and propofol during surgery, whereas the contribution of remifentanil in the absence of stimulation seems limited. In addition, our results suggest that the propofol effect site concentration provides a guide to the value at which the patient recovers consciousness. Br J Anaesth 2003; 90: 623-9
PMID: 12697590, UI: 22583255
Br J Anaesth 2003 May;90(5):617-22
Institute of Cardiology, Department of Anaesthesia and Intensive Care, Pitie-Salpetriere University Hospital, Paris, France.
BACKGROUND: Propofol-anaesthesia administrated via target-controlled infusion (TCI) has been proposed for cardiac surgery. Age-related changes in pharmacology explain why propofol dose requirement is reduced in elderly patients. However, the Marsh pharmacokinetic model incorporated in the Diprifusor propofol device does not take age into account as a covariable. In the absence of depth of anaesthesia monitoring, this limitation could cause adverse cardiovascular effects resulting from propofol overdose in older patients. We assessed the influence of age on effect-site propofol concentrations predicted by the Diprifusor and titrated to the bispectral index score (BIS) during cardiac anaesthesia. METHODS: Forty-five patients received propofol by Diprifusor and remifentanil by software including Minto model. Propofol and remifentanil effect-site concentrations were adapted to BIS (40-60) and haemodynamic profile, respectively. The influence of age on effect-site concentrations was assessed by dividing patients into two groups: young (<65 yr) and elderly (>/=65 yr). RESULTS: For a similar depth of anaesthesia, effect-site propofol concentrations were significantly lower in elderly patients at the different stages of cardiac surgery. The mean dose of propofol required to perform tracheal intubation was significantly lower in elderly patients. However, the overall doses of propofol were comparable in both groups. Neither effect-site remifentanil concentrations nor overall doses of remifentanil were significantly different between the two groups. CONCLUSIONS: In cardiac anaesthesia, target concentrations of propofol must be reduced in elderly patients. Although this probably contributes to improving intraoperative haemodynamic stability, the absence of decrease in overall dose requirement of propofol suggests that this adjustment is relatively moderate. Br J Anaesth 2003: 90: 617-22
PMID: 12697589, UI: 22583254
Br J Anaesth 2003 May;90(5):596-9
Department of Orthopaedics and Department of Anaesthesiology and Intensive Care, Faculty of Health Sciences, University of Linkoping, S-581 85, Linkoping, Sweden.
BACKGROUND: Total knee arthroplasty (TKA) is often carried out using a tourniquet and shed blood is collected in drains. Tranexamic acid decreases the external blood loss. Some blood loss may be concealed, and the overall effect of tranexamic acid on the haemoglobin (Hb) balance is not known. METHODS: Patients with osteoarthrosis had unilateral cemented TKA using spinal anaesthesia. In a double-blind fashion, they received either placebo (n=24) or tranexamic acid 10 mg kg(-1) (n=27) i.v. just before tourniquet release and 3 h later. The decrease in circulating Hb on the fifth day after surgery, after correction for Hb transfused, was used to calculate the loss of Hb in grams. This value was then expressed as ml of blood loss. RESULTS: The groups had similar characteristics. The median volume of drainage fluid after placebo was 845 (interquartile range 523-990) ml and after tranexamic acid was 385 (331-586) ml (P<0.001). Placebo patients received 2 (0-2) units and tranexamic acid patients 0 (0-0) units of packed red cells (P<0.001). The estimated blood loss was 1426 (1135-1977) ml and 1045 (792-1292) ml, respectively (P<0.001). The hidden loss of blood (calculated as loss minus drainage volume) was 618 (330-1347) ml and 524 (330-9620) ml, respectively (P=0.41). Two patients in each group developed deep vein thrombosis. CONCLUSIONS: Tranexamic acid decreased total blood loss by nearly 30%, drainage volume by approximately 50% and drastically reduced transfusion. However, concealed loss was only marginally influenced by tranexamic acid and was at least as large as the drainage volume. Br J Anaesth 2003; 90: 596-9
PMID: 12697586, UI: 22583251
Br J Anaesth 2003 May;90(5):580-588
Department of Psychology, University of Aberdeen, King's College, Aberdeen AB24 2UB, UK. Scottish Clinical Simulation Centre, Stirling Royal Infirmary, Livilands Gate, Stirling FK8 2AU, UK Department of Anaesthesia, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK.
BACKGROUND: Non-technical skills are critical for good anaesthetic practice but are not addressed explicitly in normal training. Realization of the need to train and assess these skills is growing, but these activities must be based on properly developed skills frameworks and validated measurement tools. A prototype behavioural marker system was developed using human factors research techniques. The aim of this study was to conduct an experimental evaluation to establish its basic psychometric properties and usability. METHOD: The Anaesthetists' Non-Technical Skills (ANTS) system prototype comprises four skill categories (task management, team working, situation awareness, and decision making) divided into 15 elements, each with example behaviours. To investigate its experimental validity, reliably and usability, 50 consultant anaesthetists were trained to use the ANTS system. They were asked to rate the behaviour of a target anaesthetist using the prototype system in eight videos of simulated anaesthetic scenarios. Data were collected from the ratings forms and an evaluation questionnaire. RESULTS: The results showed that the system is complete, and that the skills are observable and can be rated with acceptable levels of agreement and accuracy. The internal consistency of the system appeared sound, and responses regarding usability were very positive. CONCLUSIONS: The findings of the evaluation indicated that the ANTS system has a satisfactory level of validity, reliability and usability in an experimental setting, provided users receive adequate training. It is now ready to be tested in real training environments, so that full guidelines can be developed for its integration into the anaesthetic curriculum. Br J Anaesth 2003; 90: 580-8
PMID: 12697584
Eur J Anaesthesiol 2003 Apr;20(4):336-8
PMID: 12703842, UI: 22589347
Eur J Anaesthesiol 2003 Apr;20(4):332-3
PMID: 12703840, UI: 22589345
Eur J Anaesthesiol 2003 Apr;20(4):325-30
University of Manchester, School of Pharmacy & Pharmaceutical Sciences, Manchester, UK. katherine.payne@man.ac.uk
BACKGROUND AND OBJECTIVE: In October 2000, we conducted a national postal survey of day case consultant anaesthetists in the UK to explore the range and variation in practice of anaesthetizing a patient for day case surgery (paediatrics, urology and orthopaedics). This paper reports the findings of this national survey of paediatric day case anaesthetic practice carried out as part of a major two-centre randomized controlled trial designed to investigate the costs and outcome of several anaesthetic techniques during day care surgery in paediatric and adult patients (cost-effectiveness study of anaesthesia in day case surgery). METHODS: The survey used a structured postal questionnaire and collected data on the duration of surgical procedure; the use of premedication; the anaesthetic agents used for induction and maintenance; the fresh gas flow rates used for general anaesthesia; the use of antiemetics; and the administration of local anaesthesia and analgesia. RESULTS: The overall response rate for the survey was 74 and 63% for the paediatric section of the survey. Respondents indicated that 19% used premedication, 63% used propofol for induction, 54% used isoflurane for maintenance, 24% used prophylactic antiemetics and 85%, used a laryngeal mask. The findings of this national survey are discussed and compared with published evidence. CONCLUSIONS: This survey identifies the variation in clinical practice in paediatric day surgery anaesthesia in the UK.
PMID: 12703838, UI: 22589343
Eur J Anaesthesiol 2003 Apr;20(4):311-24
BACKGROUND AND OBJECTIVE: In October 2000, we conducted a national postal survey of consultant day case anaesthetists in the UK to explore the range and variation in the practice of anaesthetizing a patient for day case surgery (paediatrics, urology and orthopaedics). The survey was carried out as part of a larger study that comprised a major two-centre randomized controlled trial designed to investigate the costs and outcome of several anaesthetic techniques during day care surgery in paediatric and adult patients (cost-effectiveness study of anaesthesia in day case surgery). We report the findings of this national survey of adult urology and orthopaedic day case anaesthetic practice in the UK. METHODS: The survey used a structured postal questionnaire and collected data on the duration of the surgical procedure; the use of premedication; the anaesthetic agents used for induction and maintenance; the fresh gas flows used for anaesthesia; the use of antiemetics; and the administration of local anaesthesia and analgesia. RESULTS: The overall response rate for the survey was 74% (63% for urology, 67% for orthopaedics). The survey indicated the following practice in adult urology and adult orthopaedic day case surgery: 6 and 12% used premedication; propofol was the preferred induction agent (96 and 97%) and isoflurane the preferred maintenance agent (56 and 58%); 32 and 41% used prophylactic antiemetics; 86 and 93% used a laryngeal mask. CONCLUSIONS: This survey identifies the variation in current clinical practice in adult day surgery anaesthesia in the UK and discusses this variation in the context of current published evidence.
PMID: 12703837, UI: 22589342
Eur J Anaesthesiol 2003 Apr;20(4):294-7
Postgraduate Institute of Medical Education and Research, Department of Anaesthesia and Intensive Care, Chandigarh, India.
BACKGROUND AND OBJECTIVE: The implication of intrathecal lidocaine in neurological toxicity has made intrathecal bupivacaine the commonly used drug for local anaesthesia in ambulatory surgery. However, in high doses intrathecal bupivacaine may produce a high level of sensory and motor block, and arterial hypotension; discharge from hospital may be delayed. Intrathecal opioids added to low-dose local anaesthetics produce a synergistic effect without increasing the sympathetic block or delaying discharge. The aim of our study was to identify the minimum effective dose of intrathecal fentanyl that in combination with low-dose intrathecal bupivacaine would provide adequate surgical conditions without prolonging recovery. METHODS: A prospective, single, blind, randomized study was conducted in 45 adult males scheduled for minor urological procedures using intrathecal anaesthesia on a day care basis. Patients were randomly assigned to one of three groups (n = 15 each). They received bupivacaine 0.17% 5 mg--with either fentanyl 7.5 microg (fenta-7.5), 10 microg (fenta-10) or 12.5 microg (fenta-12.5) intrathecally in a total volume of 3 mL. The quality of anaesthesia, haemodynamic stability, time to two-segment and S2 regression, time to micturition, and time to discharge were assessed. RESULTS: The time to two-segment regression and S2 regression with fenta-12.5 was significantly longer than with fenta-7.5 and fenta-10 (P < 0.01). Fenta-7.5 had a significantly higher number of failed blocks (four patients) compared with fenta-12.5 (P < 0.05). The time out of bed, time to micturition and time to discharge were significantly longer with fenta-10 and fenta-12.5 compared with fenta-7.5, and also with fenta-12.5 compared with fenta-10 (P < 0.01). Haemodynamic stability did not differ for all the drug combinations. CONCLUSIONS: Fentanyl 12.5 microg added to low-dose bupivacaine (5 mg) intrathecally provides better surgical anaesthesia and increased reliability of block than intrathecal fentanyl 7.5 or 10 microg. Haemodynamic stability was the same for all dose combinations used.
PMID: 12703834, UI: 22589339
Eur J Anaesthesiol 2003 Apr;20(4):282-8
University of Vienna, Department of Anaesthesia and General Intensive Care (A & B), Vienna, Austria. klaus.hellwagner@univie.ac.at
BACKGROUND AND OBJECTIVE: We ascertained whether dreams during short general anaesthesia influence subsequent patient satisfaction and anxiety. METHODS: Fifty female patients were randomized into two groups to test for a difference between intravenous and inhalational anaesthesias. In Group Propo, anaesthesia was induced and maintained with propofol; in Group Metho-Iso, anaesthesia was induced with methohexital and maintained with isoflurane. Satisfaction and anxiety with anaesthesia were evaluated using a visual analogue scale from 0 to 100. Dream incidence rate, satisfaction and anxiety were assessed from immediately after waking until 3 months later. RESULTS: Seventeen patients (34%) dreamed during anaesthesia. There were no significant differences in satisfaction or anxiety after anaesthesia between the dreaming and non-dreaming patients (satisfaction, 92.3 +/- 21.6 versus 92.1 +/- 21.6; anxiety, 21.1 +/- 21.1 versus 30.3 +/- 32.1), or between Group Propo and Group Metho-Iso (satisfaction, 94.4 +/- 19.3 versus 90.0 +/- 23.4; anxiety, 26.0 +/- 27.6 versus 28.4 +/- 30.7). There was no significant difference in the incidence rate of dreaming with the type of anaesthesia used (Group Propo, 11 patients; Group Metho-Iso, 6 patients). CONCLUSIONS: Dreaming during general anaesthesia is common but does not influence satisfaction or anxiety after anaesthesia.
PMID: 12703832, UI: 22589337
Eur J Anaesthesiol 2003 Apr;20(4):259-81
Medical Center, Department for Anaesthesiology, Ljubljana, Slovenia. manohin@link.si
The aim of this Review is to introduce anaesthesiologists to the basic physical principles that are important for their work. A better understanding of the underlying processes during anaesthesia is required for greater safety and efficiency. Relevant physical quantities are presented along with the area of anaesthesiology where they are used. This approach provides better targeting to the needs of practising anaesthesiologists. This text has been a part of a specialist course in anaesthesiology at the University of Ljubljana for some years. Current results show that both the students and the specialist anaesthesiologists now show a better understanding of the underlying physical principles required for their work and are more successful in fulfilling the needs of their practical work.
PMID: 12703831, UI: 22589336
Eur J Anaesthesiol 2003 Mar;20(3):254; author reply 255
PMID: 12650498, UI: 22537009
Eur J Anaesthesiol 2003 Mar;20(3):234-8
Sungkyunku'an University School of Medicine, Department of Anesthesiology, Samsung Cheil Hospital, Seoul, South Korea. jenyhong@samsung.co.kr
BACKGROUND AND OBJECTIVE: The reported incidence of shoulder tip pain following laparoscopic surgery varies from 35 to 63%. This study evaluated the analgesic efficacy of either performing a prophylactic suprascapular nerve block with bupivacaine or applying a piroxicam patch to the skin over both shoulders for the relief of shoulder tip pain after laparoscopy. METHODS: Sixty healthy informed female patients were randomly assigned to one of three groups: (a) a control group (n = 20), no treatment; (b) a suprascapular nerve block group (n = 20) in which a bilateral suprascapular nerve block was performed before induction of anaesthesia with 5 mL 0.5% bupivacaine with epinephrine; and (c) a piroxicam patch group (n = 20) in which a 48 mg piroxicam patch on the skin of each shoulder was applied before induction of anaesthesia. All patients received a total intravenous anaesthesia technique with propofol, fentanyl and vecuronium. Shoulder tip and wound pain were recorded on a visual analogue pain scale at five time intervals for 24 h after surgery. RESULTS: A total of 80% of patients in the control group, 75% in the suprascapular nerve block group and 45% in the piroxicam patch group complained of shoulder tip pain during the recording period (P < 0.05). The scores for shoulder tip pain in the piroxicam patch group were significantly lower compared with the control group at 3, 6 and 12 h, and compared with the suprascapular nerve block group at 6 and 12 h. The need for analgesics was also significantly lower in the piroxicam patch group compared with the other two groups. CONCLUSIONS: Prophylactic piroxicam patches are effective and safe for the relief of shoulder tip pain after laparoscopy. Bilateral suprascapular nerve block is not effective in this setting.
PMID: 12650495, UI: 22537006
Eur J Anaesthesiol 2003 Mar;20(3):225-33
St Thomas' Hospital NHS Trust, London, UK.
BACKGROUND AND OBJECTIVE: The study was designed to identify those factors associated with early tracheal extubation following cardiac surgery. Previous studies have tended to concentrate on surgery for coronary artery bypass or on other selected cohorts. METHODS: Sequential cohort analysis of 296 unselected adult cardiac surgery patients was performed over 3 months. RESULTS: In total, 39% of all patients were extubated within 6 h, 89% within 24 h and 95% within 48 h. Delayed extubation (>6 h after surgery) appeared unrelated to age, gender, body mass index, a previous pattern of angina or myocardial infarction, diabetes, preoperative atrial fibrillation, and preoperative cardiovascular assessment, as well as other factors. Delayed tracheal extubation was associated with poor left ventricular, renal and pulmonary function, a high Euroscore, as well as the type, duration and urgency of surgery. Early extubation (<6 h) was not associated with a reduced length of stay in either the intensive care unit or in hospital compared with patients who were extubated between 6 and 24 h. In these groups, it is presumed that organizational and not clinical factors appear to be responsible for a delay in discharge from intensive care. Patients who were extubated after 24 h had a longer duration of hospital stay and a greater incidence of postoperative complications. Postoperative complications were not adversely affected by early tracheal extubation. CONCLUSIONS: In an unselected sequential cohort, both patient- and surgery-specific factors may be influential in determining the duration of postoperative ventilation of the lungs following cardiac surgery. In view of the changing nature of the surgical population, regular re-evaluation is useful in reassessing performance.
PMID: 12650494, UI: 22537005
Eur J Anaesthesiol 2003 Mar;20(3):191-8
Katholieke Universiteit Leuven, Department of Anaesthesiology, Leuven, Belgium.
BACKGROUND AND OBJECTIVE: The effect of propofol on myocardial dysfunction during ischaemia and reperfusion is controversial yet important because of its frequent use in cardiac anaesthesia. Although animal studies suggest a free radical-scavenging potential, the cardioprotective properties of propofol have not been demonstrated consistently in vivo. Previous studies focused on systolic function while diastolic function may be a more sensitive marker of ischaemic injury. The main aim was to document the effect of propofol on diastolic function in isolated, blood perfused rabbit hearts subjected to moderate global ischaemia and reperfusion. METHODS: Propofol 168 micromol L(-1), or the equivalent of its vehicle, Intralipid, was administered to 34 paced parabiotic Langendorff blood-perfused isolated rabbit hearts before and after 30 min of global normothermic ischaemia. Recovery of systolic function was quantified with the maximum rate of rise of left ventricular pressure. Diastolic performance was assessed using the time constant of the decline in left ventricular pressure (tau) and chamber stiffness (VdP/dV at 12 mmHg). RESULTS: Recovery of systolic function during reperfusion was comparable in the two groups. There was no difference in left ventricular pressure between the two groups at any time during the experiments. Chamber stiffness increased significantly during ischaemia and reperfusion in the control group (from 34 +/- 9 to 54 +/- 8 mmHg during ischaemia, and 43 +/- 5 mmHg after 30 min reperfusion; mean +/-95% confidence interval) but not in the propofol-treated group (29 +/- 5, 36 +/- 8 and 30 +/- 8 at baseline, ischaemia and 30 min reperfusion, respectively). CONCLUSIONS: Propofol has no protective effect on active relaxation or on systolic function in the present model, but it reduces ischaemic and postischaemic chamber stiffness.
PMID: 12650489, UI: 22537000
Eur J Pharmacol 2003 Apr 18;466(3):317-21
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, 2176 Health Sciences Mall, V6T 1Z3, Vancouver, B.C., Canada
Urocortin is an endogenous vasodilator peptide that is related to corticotrophin-releasing factor. We examined the haemodynamic effects of urocortin in thiobutabarbital-anaesthetized rats, via the triple-isotope microspheres technique. Urocortin (3 nmol/kg, i.v. bolus) reduced mean arterial pressure (-25 mm Hg) through a decrease in total peripheral resistance (-43%). This was associated with an increase in cardiac output (+24%) and vasodilatation of the following tissues: heart and stomach ( approximately 300% of baseline); liver, intestine, caecum/colon, skeletal muscle and skin ( approximately 200%); and testes ( approximately 150%). Arterial conductances of the kidneys, spleen and brain were unaffected by urocortin. Neither the vehicle (0.9% NaCl) nor a low dose of urocortin (0.3 nmol/kg) altered any measurements. Therefore, urocortin causes generalized vasodilatation as follows: heart and stomach>liver, intestine, caecum/colon, skeletal muscle and skin>testes.
PMID: 12694815, UI: 22581274
J Cardiothorac Vasc Anesth 2003 Apr;17(2):284-286
PMID: 12698422
J Cardiothorac Vasc Anesth 2003 Apr;17(2):281-3
Departments of Anaesthesiology and double dagger Cardiothoracic Surgery, G.B. Pant Hospital, New Delhi, India.
PMID: 12698421, UI: 22583922
J Cardiothorac Vasc Anesth 2003 Apr;17(2):236-9
Department of Anaesthesiology, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Trivandrum, India.
PMID: 12698410, UI: 22583911
J Cardiothorac Vasc Anesth 2003 Apr;17(2):232-5
Division of Cardiac Anesthesia, Department of Anesthesia and Critical Care, Beth Israel Hospital, and the Department of Anesthesia, Harvard Medical School, Boston, MA.
PMID: 12698409, UI: 22583910
J Cardiothorac Vasc Anesth 2003 Apr;17(2):226-9
Department of Anesthesia, Manchester Royal Infirmary, Manchester, United Kingdom.
PMID: 12698407, UI: 22583908
J Cardiothorac Vasc Anesth 2003 Apr;17(2):221-225
Service d'Anesthesie-Reanimation and Equipe d'Accueil 1896, Hopital Cardiovasculaire et Pneumologique Louis Pradel, Lyon, France; Laboratoire Central de Microbiologie, Hopital Edouard Herriot, Lyon, France; and Service de Chirurgie Cardiaque, Hopital Cardiovasculaire et Pneumologique, Lyon, France.
OBJECTIVE: Antibiotic prophylaxis is recommended in pediatric cardiac surgery, but no data concerning the current antibiotic regimen were available. DESIGN: Prospective study from April to June 2000. SETTING: University hospital operating room and postoperative intensive care unit. PARTICIPANTS: Nineteen consecutive infants less than 10 kg with normal renal function undergoing cardiac surgery with cardiopulmonary bypass longer than 30 minutes. INTERVENTIONS: Intravenous administration of cefazolin, 40 mg/kg, and gentamicin, 5 mg/kg, at induction of anesthesia; followed by cefazolin, 35 mg/kg every 8 hours, and gentamicin, 2 mg/kg every 12 hours, over 48 hours. MEASUREMENTS AND MAIN RESULTS: Levels of serum antibiotics were measured: cefazolin (microbiologic) and gentamicin (fluorescence immunoassay) with 8 intraoperative and 5 postoperative samplings. Intraoperatively, cefazolin levels decreased from 166 +/- 44 (mean +/- standard deviation) down to 54 +/- 16 &mgr;g/mL and gentamicin from 20.8 +/- 9.5 down to 5.9 +/- 1.5 &mgr;g/mL. The postoperative trough levels were 12 +/- 7, 15 +/- 10, and 19 +/- 22 &mgr;g/mL for cefazolin and 1.1 +/- 0.5, 0.8 +/- 0.4, and 0.8 +/- 0.9 &mgr;g/mL for gentamicin. CONCLUSIONS: Antibiotic serum levels are consistent with satisfactory efficacy, but intraoperative gentamicin peak levels appeared too high. Copyright 2003 Elsevier Inc. All rights reserved.
PMID: 12698406
J Cardiothorac Vasc Anesth 2003 Apr;17(2):188-92
Service d'Anesthesie, Hopital Foch, Suresnes, France; and Service d'Anesthesie-Reanimation Chirurgicale, Hopital Europeen Georges Pompidou, Paris, France.
OBJECTIVE: To assess the accuracy of respiratory-induced systolic pressure variation and its components to detect low left ventricular preload. DESIGN: Prospective study. SETTING: University hospital. PARTICIPANTS: Sixty-seven patients undergoing major surgery under general anesthesia. INTERVENTIONS: Transesophageal echocardiographic measurements during apnea and mechanical ventilation. MEASUREMENTS AND MAIN RESULTS: Respiratory-induced systolic pressure variation and its components and left ventricular end-diastolic area obtained by transesophageal echocardiography were noted simultaneously. Arterial pressure indices did not allow a reliable diagnosis of a low left ventricular end-diastolic area using a cut-off value of 7.9 cm(2)/m(2) (inferior boundary of the interquartile range of the areas measured in the authors' group). CONCLUSIONS: These results suggest that systolic pressure variations noticed after induction of general anesthesia do not reflect low left ventricular preload in nonhypotensive patients. Copyright 2003 Elsevier Inc. All rights reserved.
PMID: 12698400, UI: 22583901
J Cardiothorac Vasc Anesth 2003 Apr;17(2):160-4
Wockhardt Heart Institute, Bangalore, Karnataka, India.
OBJECTIVES: The feasibility of the use of high thoracic epidural anesthesia as a sole anesthetic in patients undergoing beating heart coronary revascularization avoiding general anesthesia was studied. DESIGN: A prospective study. SETTING: A tertiary care medical center. INTERVENTIONS: Fifteen patients underwent beating heart coronary artery revascularization without endotracheal general anesthesia, between October 2001 to May 2002, using high thoracic epidural anesthesia and analgesia. All the patients underwent epidural catheterization on the evening before the surgery. MEASUREMENTS AND MAIN RESULTS: The patients received 36 grafts (single, n = 5; double, n = 3; triple, n = 3; quadruple, n = 4). There were 3 female patients and 12 male patients with mean age of 60.6 +/- 5.9 years. Two patients underwent repeat coronary artery bypass. All the patients underwent off-pump coronary artery bypass graft surgery; 2 patients underwent grafting via left thoracotomy and the rest through a midsternotomy. There was no conversion to general anesthesia or cardiopulmonary bypass, and there was no mortality. Mean length of stay in the intensive care unit was 18.2 +/- 4.2 hours and in the hospital was 3.2 +/- 1.2 days. CONCLUSION: Experience confirms the feasibility of performing multiple coronary artery bypasses in conscious patients without endotracheal general anesthesia. Copyright 2003 Elsevier Inc. All rights reserved.
PMID: 12698395, UI: 22583896
J Cardiothorac Vasc Anesth 2003 Apr;17(2):154-9
Servicio de Anestesiologia, Hospital General de Alicante, Alicante, Spain.
OBJECTIVE: To evaluate the risk of neurologic complications caused by an epidural hematoma in a series of patients who had coronary artery bypass graft surgery with cardiopulmonary bypass under combined general and thoracic epidural anesthesia (TEA). DESIGN: Prospective observational study. SETTING: General hospital associated with a university. PARTICIPANTS: Seven hundred fourteen patients who had coronary artery bypass grafting surgery over a 7-year period. INTERVENTIONS: An epidural catheter was inserted at T(1)-T(3) as soon as the patient was in the operating room and local anesthetic was administered as a bolus and then as a continuous infusion throughout the operation and postoperatively. A set of safety guidelines was routinely followed. A protocol for postoperative neurologic evaluation was used to rule out any signs of spinal compression. MEASUREMENTS AND MAIN RESULTS: Preoperatively, a battery of coagulation tests was systematically performed including APTT, platelet count, and prothrombin time. Antiplatelet drugs (aspirin) were stopped at least 7 days before surgery. No patient required parenteral opiates postoperatively. Seventy-five percent of the patients were extubated in the operating room. No clinical epidural hematomas were detected. CONCLUSION: In this study, some of the benefits previously reported during cardiac surgery under TEA, such as excellent analgesia and early extubation, were confirmed. In addition, the series adds further evidence that adherence to a set of standard safety measures, in this setting, averts the occurrence of symptomatic epidural hematomas. Copyright 2003 Elsevier Inc. All rights reserved.
PMID: 12698394, UI: 22583895
J Cardiothorac Vasc Anesth 2003 Apr;17(2):151-3
Professor, Department of Anesthesiology, The Ohio State University College of Medicine and Public Health, Columbus, OH.
PMID: 12698393, UI: 22583894