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Items 1 - 5 of 5 |
One page. |
"We are the world (of anaesthesia)": reflections on (and lessons learned at) the World Congress of Anaesthesiologists 2004.
Kuczkowski KM, Fernandez CL.
Departments of Anesthesiology And Reproductive Medicine, University of California San Diego, San Diego, CA, USA.
Publication Types:
PMID: 15581730 [PubMed - in process]
Anaesthesia for spinal surgery in adults.
Cardan E, Appleton PJ, Raw D.
Southampton, UK.
PMID: 15583212 [PubMed - in process]
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Editorial I: Location, location, location! Ultrasound imaging in regional anaesthesia.
Denny NM, Harrop-Griffiths W.
Department of Anaesthesia, Queen Elizabeth Hospital, King's Lynn, Norfolk PE30 4ET, UK.
PMID: 15583209 [PubMed - in process]
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Influence of anaesthetic and analgesic techniques on outcome after surgery.
Bonnet F, Marret E.
Service d'Anesthesie-Reanimation, Hopital Tenon, Assistance Publique Hopitaux de Paris, 4 rue de la Chine, F-75970 Paris cedex 20, France.
Postoperative symptoms and complications can be prevented by a suitable choice of anaesthetic and analgesic technique for specific procedures. The aim of analgesic protocols is not only to reduce pain intensity but also to decrease the incidence of side-effects from analgesic agents and to improve patient comfort. Moreover, adequate pain control is a prerequisite for the use of rehabilitation programmes to accelerate recovery from surgery. Thus, combining opioid and/or non-opioid analgesics with regional analgesic techniques not only improves analgesic efficacy but also reduces opioid demand and side-effects such as nausea and vomiting, sedation, and prolongation of postoperative ileus. Although all attempts to demonstrate that regional anaesthesia and analgesia decrease postoperative mortality are unsuccessful, there is evidence supporting a reduction in pulmonary complications after major abdominal surgery, and an improvement in patient rehabilitation after orthopaedic surgery. When such techniques are used, cost-benefit analysis should be considered to determine suitable analgesic protocols for specific surgical procedures.
PMID: 15579487 [PubMed - as supplied by publisher]
Contrasting anesthetic sensitivities of T-type Ca2+ channels of reticular thalamic neurons and recombinant Cav3.3 channels.
Joksovic PM, Brimelow BC, Murbartian J, Perez-Reyes E, Todorovic SM.
Reticular thalamocortical neurons express a slowly inactivating T-type Ca(2+) current that is quite similar to that recorded from recombinant Cav3.3b (alpha1Ib) channels. These neurons also express abundant Cav3.3 mRNA, suggesting that it underlies the native current. Here, we test this hypothesis by comparing the anesthetic sensitivities of recombinant Cav3.3b channels stably expressed in HEK 293 cells to native T channels in reticular thalamic neurons (nRT) from brain slices of young rats. Barbiturates completely blocked both Cav3.3 and nRT currents, with pentobarbital being about twice more potent in blocking Cav3.3 currents. Isoflurane had about the same potency in blocking Cav3.3 and nRT currents, but enflurane, etomidate, propofol, and ethanol exhibited 2-4 fold higher potency in blocking nRT vs Cav3.3 currents. Nitrous oxide (N2O; laughing gas) blocked completely nRT currents with IC50 of 20%, but did not significantly affect Cav3.3 currents at four-fold higher concentrations. In addition, we observed that in lower concentration, N2O reversibly increased nRT but not Cav3.3 currents. In conclusion, contrasting anesthetic sensitivities of Cav3.3 and nRT T-type Ca(2+) channels strongly suggest that different molecular structures of Ca(2+) channels give rise to slowly inactivating T-type Ca(2+) currents. Furthermore, effects of volatile anesthetics and ethanol on slowly inactivating T-type Ca(2+) channel variants may contribute to the clinical effects of these agents.
PMID: 15582908 [PubMed - as supplied by publisher]
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