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[Spinal anaesthesia.]
[Article in German]
Gerheuser F, Crass D.
Klinik fur Anasthesiologie und Operative Intensivmedizin, Zentralklinikum Augsburg, .
In spinal anaesthesia, surgical analgesia and in most cases motor block is achieved by injecting one or more drugs into the cerebrospinal fluid. As one of the earliest methods of anaesthesia it was introduced into clinical practice in the late nineteenth century. Although later on it was more or less replaced by "modern" general anaesthesia, it has regained popularity due to its benefits for certain patient populations. In spite of being a technically simple procedure, performing spinal anaesthesia requires a sound knowledge of applied physiology and pharmacology, especially in high-risk groups such as pregnant women or former preterm babies. For some patients even under anticoagulant therapy, spinal anaesthesia might be the best option, considering the individual risk of alternative methods.
PMID: 16317479 [PubMed - as supplied by publisher]
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[The GABA(A) receptor family Possibilities for the development of better anesthetics.]
[Article in German]
Drexler B, Grasshoff C, Rudolph U, Unertl K, Antkowiak B.
Abteilung fur Anaesthesiologie und Intensivmedizin, Universitatsklinikum, Tubingen.
ABTRACT: Clinically used anesthetics show amnestic, sedative, hypnotic and immobilizing properties. On a molecular level these drugs affect several receptors in the cell membrane of neurons. By using genetically engineered mice a linkage can now be made between actions on certain receptors and clinically desired and undesired effects. Experiments show that a certain GABA(A) receptor subtype mediates hypnosis and immobility, whereas another subtype is involved in side-effects like sedation and hypothermia. These findings form the basis for the development of new drugs, acting highly specific and with fewer side-effects.
PMID: 16315024 [PubMed - as supplied by publisher]
[Haemorrhagic shock during cerebrospinal fluid shunt procedure. Reassessment of the anaesthetic or surgical practice?]
[Article in French]
Combettes E, Blanot S, Cuttaree H, Zerah M, Orliaguet G.
Departement d'anesthesie-reanimation chirurgicale, hopital Necker-Enfants-malades, 149, rue de Sevres, 75743 Paris cedex 15, France.
We report two cases of perioperative haemorrhagic shock after accidental puncture of trunc vessels, during emergency shunt procedures in children who suffer of severe intracranial hypertension. In both cases it's the peritoneal internalization of the shunt with Portnoy trocar which is responsible of these deep vascular wounds. Evolution was favourable in both cases with cardiovascular resuscitation, transfusion and surgical haemostatic correction. Few days later, an internal shunt was performed in the second patient, while the first patient did not need shunt anymore. These two accidents lead to the discussion of the surgical procedure with surgeons, in order to have a better prevention against this complication. We also discuss our anaesthesiological practice from preoperative to perioperative period of this usually non-haemorrhagic surgical procedure.
PMID: 16311005 [PubMed - as supplied by publisher]
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[What are the changes in paediatric anaesthesia practice afforded by new anaesthetic ventilators?]
[Article in French]
Odin I, Nathan N.
Departement d'anesthesie-reanimation chirurgicale, CHU Dupuytren, 2, avenue Martin-Luther-King, 87042 Limoges, France.
Because of specific paediatric respiratory physiology (mainly decreased compliance and functional residual capacity, increased O(2) demand and CO(2) production), ventilators for paediatric anaesthesia need to be powerful and able to deliver small volumes at a high rate without compression volume loss. The compensation of compliance now available on every anaesthesia machine, compensates for the volume of gas lost by compression in the circuit tubing allowing the tidal volume to reach preset commands, even for bellow in box respirators. Preset tidal volume is then totally delivered to the lung by volume-controlled ventilation because it becomes independent of total pulmonary compliance and fresh gas flow. Increased precision of electronic flowmeters and better air-tightness of circuits allow reducing with precision fresh gas flow to values approaching children's O(2) consumption and N(2)O diffusion. New modes of ventilation are now available on anaesthesia machine. Pressure controlled mode, by increasing and maintaining mean airway pressures, ameliorates intrapulmonary gas distribution and compensates for the gas leak from uncuffed tracheal tubes. Unsteady tidal volume resulting from variation of total compliance, is the main drawback of pressure-controlled ventilation that may be overcome by using the "autoflow" mode (better described as a pressure controlled mode ensuring tidal volume) available with one of the last generation of ventilators. Increased accuracy and security of the mode "pressure assist" might increase the use of spontaneous ventilation in paediatric anaesthesia even for low weight children. However tidal volume remains variable with compliance and depth of anaesthesia, which may require several adjustments of ventilator's settings. The clinical conditions (mainly airway control) of pressure assist use for children less than 10 kg should be elucidated before recommending its use.
PMID: 16310339 [PubMed - as supplied by publisher]
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[Preoperative information for paediatric patients. The anaesthesiologist point of view.]
[Article in French]
Orliaguet G.
Departement d'anesthesie-reanimation, hopital Necker-Enfants-malades, Assistance-publique-hopitaux-de-Paris, universite Rene-Descartes Paris-V, 149, rue de Sevres, 75743 Paris cedex 15, France.
Medical information is mandatory before any medical procedure, including pediatric anesthesia. Preoperative information covers many aspects, including medico-psychologic and judicial aspects. When the patient is a child, information must be delivered to the parents in priority. However, the French law has given a particular attention to the opinion of the child. In 70% of the cases, preoperative anxiety of the parents is more related to anesthesia than to the surgical procedure itself. We have to explain the most frequent adverse effects, as well as the more severe and well known complications to the parents, even though they are very infrequent. The only cases where preoperative information is not required are: emergency cases and refusal of the patient or the parents to be informed. While information is necessarily oral, it may be completed using a written document. The quality of the preoperative information directly influences the quality of the psychological preoperative preparation of the parents, and thereafter of the child. Preoperative preparation programs have been developed, but controversial results have been observed. The great majority of the studies on preoperative programs were performed in the USA, where the demand for preoperative information is very important. It is far from sure that the results of all these studies may be extrapolated to French parents, and French studies are needed.
PMID: 16310336 [PubMed - as supplied by publisher]
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[Anaesthetic particularities for children with tumours.]
[Article in French]
Lejus C.
Service anesthesie-reanimation chirurgicale, Hotel-Dieu-hopital Mere-Enfant, CHU de Nantes, 44093 Nantes cedex, France.
Objectives. - To present the more frequent solid tumors, that require a general anaesthesia and to describe the particularities of the anaesthetic management. Data sources and extraction. - The PUBMED database was searched for articles (1990 - 2005) combined with references analysis of major articles on the topics. Data synthesis. - Neoplasma is the first cause of paediatric death. In children less than 5 years of age, neuroblastoma and nephroblastoma are the more frequent of the tumour. The incidence of each pathology is low. However a general anaesthesia is required in numerous situations: bone marrow aspiration and biopsy, central venous catheter insertion, various biopsies under computed tomography, ultrasound, thoracoscopy or laparoscopy, MRI scan, surgery and body radiation. The key points of successful anaesthetic management include complete preoperative evaluation together with the oncology paediatric team. Particularly, cardiotoxicity may result from chemotherapy and hypertension is frequently associated with neuroblastoma and nephroblastoma. Mediastinal location of lymphomas induced a significant risk of cardiopulmonary complications during induction of general anaesthesia. A peak expiratory flow rate or a tracheal cross-section area less than 50% of predicted values are contraindication to general anaesthesia. Cephalic rhabdomyosarcoma may be responsible of difficult airway management. Specific guidelines are available for platelet and red cell transfusion in paediatric oncology patients. Surgical antibioprophylaxis are adapted in immunodepressed children to a potential increased risk of postoperative infectious complications, according personal previous history, microbiological ecology and body bacterial flora. Dosage of anaesthetic agents takes into account denutrition, hydroelectrolytic disturbances and hypovolemia.
PMID: 16310335 [PubMed - as supplied by publisher]
Obese parturients have lower epidural local anaesthetic requirements for analgesia in labour.
Panni MK, Columb MO.
Division of Women's Anesthesia, Department of Anesthesiology, Duke University Medical Centre, Durham, NC 27710, USA. Moeen.K.Panni@uth.tmc.edu
BACKGROUND: There are no studies comparing local anaesthetic requirements for obese and normal parturients. Obesity has been associated with a higher incidence of Caesarean section and higher levels of epidural block have also been found in obese obstetric patients, suggesting they may require less local anaesthetic. The aim of our study was to estimate the minimum local analgesic concentration (MLAC) of bupivacaine for obese and non-obese parturients. METHODS: Otherwise healthy parturients (n=32) requesting epidural analgesia were enrolled in this up-down sequential allocation study. Women were in active labour (3-6 cm cervical dilatation) with visual analogue pain scores (VAPS) >40/100 mm. Subjects with BMI >30 kg m(-2) were allocated to the obese group and BMI < or = 30 kg m(-2) were allocated to the normal group. The initial epidural dose for both groups was 20 ml 0.1% w/v bupivacaine (20 mg), with a dosing increment of 0.01% w/v VAPS < or = 10/100 mm defined effective analgesia. The MLAC was estimated using up-down reversals and probit regression with P<0.05 as significant. RESULTS: Groups were similar except for BMI and weight (P<0.001). Local anaesthetic requirements were significantly (P<0.001) reduced by a factor of 1.68 (95% CI 1.32-2.29) in the obese group, with significantly higher initial level of block (P<0.001). CONCLUSION: We found obese parturients to have significantly decreased epidural bupivacaine analgesic requirements. A contributing factor to obese patients having more difficult labours may be that relatively larger doses of local anaesthetic are administered than actually required. It may be worth considering lowering the concentrations and doses with which we initiate analgesia in obese parturients.
PMID: 16311280 [PubMed - in process]
Anaesthetists' attitudes to intraoperative death.
White SM, Akerele O.
St. Thomas' Hospital, Department of Anaesthesia, London, UK. igasbest@hotmail.com
BACKGROUND AND OBJECTIVES: A recent survey in the British Medical Journal reported the attitudes of orthopaedic surgeons towards the intraoperative death of a patient. Several replies to this article were from anaesthetists, who pointed out that other staff might be affected by 'death on the table'. We designed a questionnaire survey to assess the attitudes of anaesthetists, concerning intraoperative death. METHODS: Three hundred anonymized questionnaires were distributed to 12 anaesthetic departments throughout England. RESULTS: Two hundred and fifty-one replies were received (84% response rate); 92% of respondents had experienced an intraoperative death, the majority of deaths being expected (60%) and non-preventable (77%), occurring mainly during emergency surgery (80%), particularly involving vascular surgery (41% of cases); 87% had administered another general anaesthetic in the following 24 h, most without their professional ability being compromised (77%). CONCLUSIONS: This survey shows that anaesthetists are highly likely to experience intraoperative death, the consequences of which can be extremely stressful. Although the majority of anaesthetists (71%) agreed that it was reasonable for medical staff not to take part in operations for 24 h after an intraoperative death, fewer (25%) thought the proposal practicable. Nevertheless, all departments should provide for the discontinuation of further operations, if the circumstances require it. Consideration should be given by all departments of anaesthesia towards the prevention of intraoperative death, and the management of its aftermath, including the provision of support for psychologically traumatized staff.
PMID: 16318666 [PubMed - in process]
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Hyperbaric bupivacaine affects the doses of midazolam required for sedation after spinal anaesthesia.
Toprak HI, Ozpolat Z, Ozturk E, Ulger MH, Sagir O, Ersoy MO.
Medical School of Inonu University, Department of Anaesthesiology, Malatya, Turkey. hilksen@inonu.edu.tr
BACKGROUND AND OBJECTIVE: Patients having spinal anaesthesia with hyperbaric bupivacaine may become sensitive to sedative drugs but no data exists about any dose-related effect of the local anaesthetic on the sedative requirement. We aimed to investigate whether hyperbaric bupivacaine dose in spinal anaesthesia has any effect on midazolam requirements. METHODS: Sixty unpremedicated patients were allocated to three equal groups. Patients in Groups I and II received hyperbaric bupivacaine 0.5% 10 and 17.5 mg respectively for spinal anaesthesia and Group III was a control group without spinal anaesthesia. In Groups I and II, after the evaluation of sensory block, patients received intravenous midazolam 1 mg per 30 s until the Ramsay sedation score reached 3 (drowsy but responsive to command). In Group III, general anaesthesia was induced after sedation score had reached 3 using midazolam. The total dose of midazolam (mg kg(-1)) given to each patient, the level of sensory block and complications were recorded. RESULTS: The level of sensory block was higher in Group II (T7) than Group I (T9) (P < 0.01). The doses of midazolam were 0.063 mg kg(-1) in Group I, 0.065 mg kg(-1) in Group II and 0.101 mg kg(-1) in Group III (P < 0.001). There was no correlation between level of sensory block and dose of midazolam in Group I (r = -0.293, P = 0.21) and Group II (r = 0.204, P = 0.39). CONCLUSIONS: Different doses of hyperbaric bupivacaine for spinal anaesthesia do not affect the midazolam requirements for sedation. However, spinal anaesthesia with hyperbaric bupivacaine with a maximum spread in the middle thoracic dermatomes may be associated with sedative effects and thus a reduced need for further sedation with midazolam.
PMID: 16318659 [PubMed - in process]
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Levobupivacaine and fentanyl for spinal anaesthesia: a randomized trial.
Lee YY, Muchhal K, Chan CK, Cheung AS.
Kwong Wah Hospital, Department of Anaesthesiology and Operating Theatre Services, Kowloon, Hong Kong SAR. yylee@ha.org.hk
BACKGROUND AND OBJECTIVE: Levobupivacaine 0.5% and racemic bupivacaine 0.5% are equally effective in spinal anaesthesia. Fentanyl has been used as an adjunct to racemic bupivacaine in spinal anaesthesia. At the time this study was designed, there was no published study on the intrathecal use of 0.5% levobupivacaine with fentanyl. METHODS: This prospective, randomized, double-blind study compared the clinical efficacy, motor block and haemodynamic effects of using 2.6 mL of 0.5% levobupivacaine alone (25 patients) and 2.3 mL of 0.5% levobupivacaine with fentanyl 15 microg in 0.3 mL (25 patients) for spinal anaesthesia in urological surgery. The study solution was injected into the subarachnoid space at the L3-L4 interspace. RESULTS: There were no significant differences between the two groups in the haemodynamic changes, and quality of sensory and motor block. Anaesthesia was adequate and patient satisfaction was good in all cases. Side-effects were minor and infrequent with both regimes. CONCLUSIONS: We conclude that 2.3 mL of 0.5% levobupivacaine with fentanyl 15 microg is as effective as 2.6 mL of 0.5% levobupivacaine alone in spinal anaesthesia for urological surgery. Further studies may be directed to find the optimal combination of levobupivacaine and opioid with maximal haemodynamic stability and least motor block.
PMID: 16318658 [PubMed - in process]
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A mutation in the local anaesthetic binding site abolishes toluene effects in sodium channels.
Gauthereau MY, Salinas-Stefanon EM, Cruz SL.
Departamento de Farmacobiologia, Cinvestav. Calzada de los Tenorios #235, Col. Granjas Coapa, Mexico, D.F. 14330, Mexico.
Toluene is a solvent of abuse that inhibits cardiac sodium channels in a manner that resembles the action of local anaesthetics. The purpose of this work was to analyze toluene effects on skeletal muscle sodium channels with and without beta1 subunit (Nav1.4+beta1 and Nav1.4-beta1, respectively) expressed in Xenopus laevis oocytes and to compare them with those produced in the F1579A mutant channel lacking a local anaesthetic binding site. Toluene inhibited Nav1.4 sodium currents (IC50=2.7 mM in Nav1.4+beta1 and 2.2 mM in Nav1.4-beta1 in a concentration dependent way. Toluene (3 mM) blocked sodium currents in Nav1.4 channels proportionally throughout the entire current-voltage relationship producing inactivation at more negative potentials. Minimal inhibition was produced by 3 mM toluene in F1579A mutant channels. Recovery from inactivation was slower both in Nav1.4 and F1579A channels in the presence of 3 mM toluene. The solvent blocked sodium currents in a use-dependent and frequency-dependent manner in Nav1.4 channels. A single mutation in the local anaesthetic binding site of Nav1.4 channels almost abolished toluene effects. These results suggest that this site is important for toluene action.
PMID: 16316648 [PubMed - in process]
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