26 Luglio 2001
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Int J Dermatol 2001 Mar;40(3):210-2
Psoriasis and Skin Treatment Center, University of California San Francisco, 94143, USA. jymkoo@orca.ucsf.edu
Publication Types:
PMID: 11422529, UI: 21316265
J R Soc Med 2001 Aug;94(8):425-6
Department of Ophthalmology, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK.
[Medline record in process]
PMID: 11461992, UI: 21354655
JAMA 2001 Jul 4;286(1):38-9
PMID: 11463035, UI: 21337135
MMWR Morb Mortal Wkly Rep 2001 Jul 6;50(26):560-2
On November 13, 2000, health-care providers at a hospital in Winston-Salem, North Carolina, contacted the local health department about three cases of listeriosis within a 2-week period in recent Mexican immigrants. The North Carolina General Communicable Disease Control Branch, in collaboration with the Forsyth County Health Department, the North Carolina Departments of Agriculture and Consumer Services (NCDA&CS) and Environment and Natural Resources, the Food and Drug Administration (FDA), and CDC investigated this outbreak of Listeria monocytogenes infections. This report summarizes the results of the investigation, which implicated noncommercial, homemade, Mexican-style fresh soft cheese produced from contaminated raw milk sold by a local dairy farm as the causative agent. Culturally appropriate education efforts are important to reduce the risk for L. monocytogenes transmission through Mexican-style fresh soft cheese.
PMID: 11456331, UI: 21349170
N Engl J Med 2001 Jul 12;345(2):79-84
Department of Medicine, New York Medical College, Valhalla 10595, USA.
BACKGROUND: It is unclear whether antimicrobial treatment after an Ixodes scapularis tick bite will prevent Lyme disease. METHODS: In an area of New York where Lyme disease is hyperendemic we conducted a randomized, double-blind, placebo-controlled trial of treatment with a single 200-mg dose of doxycycline in 482 subjects who had removed attached I. scapularis ticks from their bodies within the previous 72 hours. At base line, three weeks, and six weeks, subjects were interviewed and examined, and serum antibody tests were performed, along with blood cultures for Borrelia burgdorferi. Entomologists confirmed the species of the ticks and classified them according to sex, stage, and degree of engorgement. RESULTS: Erythema migrans developed at the site of the tick bite in a significantly smaller proportion of the subjects in the doxycycline group than of those in the placebo group (1 of 235 subjects [0.4 percent] vs. 8 of 247 subjects [3.2 percent], P<0.04). The efficacy of treatment was 87 percent (95 percent confidence interval, 25 to 98 percent). Objective extracutaneous signs of Lyme disease did not develop in any subject, and there were no asymptomatic seroconversions. Treatment with doxycycline was associated with more frequent adverse effects (in 30.1 percent of subjects, as compared with 11.1 percent of those assigned to placebo; P<0.001), primarily nausea (15.4 percent vs. 2.6 percent) and vomiting (5.8 percent vs. 1.3 percent). Erythema migrans developed more frequently after untreated bites from nymphal ticks than after bites from adult female ticks (8 of 142 bites [5.6 percent] vs. 0 of 97 bites [0 percent], P=0.02) and particularly after bites from nymphal ticks that were at least partially engorged with blood (8 of 81 bites [9.9 percent], as compared with 0 of 59 bites from unfed, or flat, nymphal ticks [0 percent]; P=0.02). CONCLUSIONS: A single 200-mg dose of doxycycline given within 72 hours after an I. scapularis tick bite can prevent the development of Lyme disease.
PMID: 11450675, UI: 21321467
N Engl J Med 2001 Jul 12;345(2):133-4
PMID: 11450662, UI: 21321475
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