Br J Dermatol 2001 Sep;145(3):490-5
Department of Human and Hereditary Pathology, Institute of Dermatology and Institute of Haematology, University of Pavia, IRCCS Policlinico San Matteo, Piazzale Golgi 2, 27100 Pavia, Italy.
Autologous bone marrow transplantation and autologous peripheral blood stem cell transplantation (APBSCT) are alternative therapeutic options in the treatment of various malignancies. We describe four patients undergoing APBSCT for malignancies; they developed a cutaneous eruption characterized by confluent erythematous and hyperpigmented patches within the flexural areas during the first month after transplantation. The lesions were poorly circumscribed without epidermal changes such as scaling, xerosis, erosions or atrophy. The skin patches were treated with topical corticosteroids and resolved within a few days with discoloration. Histopathological findings were characterized by focal vacuolar degeneration of the basal layer with epidermal dysmaturation. We believe that these cutaneous eruptions are consistent with an interplay of high-dose chemotherapy and local factors such as friction, local skin temperature and eccrine gland distribution, which could explain the constant location of this eruption in the axillae and genital area.
PMID: 11531844, UI: 21423098
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Forensic Sci Int 2001 Nov 1;122(2-3):167-71
Andhra Pradesh State Forensic Science Laboratory, Red Hills, 500004, Hyderabad, India
[Medline record in process]
Medical records of (i) toxico-medico-legal death cases from three districts of Telengana region in the state of Andhra Pradesh, viz. Hyderabad, Ranga Reddy and Medak, and (ii) clinical toxicology cases in suspected poisoning from hospitals in and around Hyderabad city were examined for a period of 5 calendar years. The age group at risk in both the types of cases is 15-24. The cause of suicides includes physical illness, family/spouse problems and financial problems. Labourers form a dominant risk group in rural and semi-urban industrial area, whereas in urban area the employees were the dominant risk group. The agricultural pesticides and household insecticides were the predominant poisons used for suicide purposes.
PMID: 11672973, UI: 21526951
Int J Dermatol 2001 Jun;40(6):412-4
Department of Dermatology, Santa Casa da Misericordia, Rio de Janeiro, and IFF/CPqHEC, Fiocruz, Brazil.
PMID: 11589749, UI: 21474182
Int J Dermatol 2001 May;40(5):323-6
Department of Medicine, Komfo Anokye Teaching Hospital, and School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. prosperdoe@yahoo.com
BACKGROUND: Although diseases of the skin have been studied in some African countries, the provision of dermatology services is as yet a relatively underdeveloped aspect of medicine in sub-Saharan Africa. OBJECTIVE: To determine the pattern of skin diseases seen in a sub-Saharan community and to compare it with that seen in a European community. METHODS: The diagnoses of the principal presenting complaint of 2254 consecutive new patients seen at the dermatology clinic of Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana, are presented and compared with those of 3383 consecutive new patients seen at the dermatology clinic of The William Harvey Hospital (WHH), Ashford, Kent, UK. RESULTS: The most common conditions in Ghana were infections (46.3%; UK, 12%). In the UK, the most common conditions were malignant and premalignant diseases of the skin (22.2%; Ghana, 0.5%) and benign tumors (16.8%; Ghana, 0.5%). Dermatitis was common in both countries (Ghana, 18.4%; UK, 16.0%). Psoriasis was more common in the UK (6.2%) than in Ghana (0.4%). In Ghana, fixed drug eruption, mainly due to cotrimoxazole (Septrin), was not rare (27 cases), and complications from cosmetic skin lightening creams were a frequent problem among women (86 cases). No cases of rosacea were found in Ghana, but it was not uncommon in the UK (1.6%). CONCLUSIONS: The patterns of skin diseases are different in the two countries. It is hoped that this study may help to catalyze the further development of dermatology services in Ghana.
PMID: 11554993, UI: 21439360
Lancet 2001 Oct 6;358(9288):1187
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N Engl J Med 2001 Oct 18;345(16):1213
PMID: 11642246, UI: 21468857
N Engl J Med 2001 Oct 18;345(16):1212-3
PMID: 11642245, UI: 21468856
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