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Hum Exp Toxicol 2001 Nov;20(11):597-9
Second Department of Internal Medicine, Venizelion Hospital, Heraklion, Greece.
[Medline record in process]
Paraquat is a synthetic, nonselective, contact herbicide, which causes injury to tissues following contact. When ingested in sufficient amounts, paraquat has life-threatening effects on the gastrointestinal tract, lungs, kidney, liver, heart and other organs. This is a case report of a 15-year-old girl from an agricultural area who was admitted to hospital for treatment. She presented with discomfort, nausea and vomiting. She had drunk a small wine glass full of paraquat. After 18 days in the hospital, the girl developed neutropenia. This is the first reported case of paraquat poisoning-induced neutropenia.
PMID: 11926615, UI: 21923575
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Hum Exp Toxicol 2001 Nov;20(11):551-62
Academic Department of Accident and Emergency Medicine, Imperial College School of Medicine, St Mary's Hospital, London, UK.
Petroleum products are highly complex chemical mixtures consisting predominantly of hydrocarbons. Their composition varies with source and intended use of the product. Virtually all are blended products that come into contact with man in a wide range of circumstances. Their toxicity for man is generally low and the use of additives rarely affects the toxicity of the final product. Because products are blended to meet performance, and not chemical specifications, their composition varies significantly. Management of toxicity benefits from simplified guidelines that consider the product by its type. Management in most cases is symptomatic, but the doctor needs to be aware of the potential for development of sequelae such as aspiration pneumonia and central nervous system (CNS) depression. Local and systemic effects of exposure to hydrocarbons are reviewed, as are immediate assessment and recommended management of acute exposure to petroleum products. Because of the large scope of this subject, this paper limits itself to acute toxicity of petroleum products encountered inthe public domain. It does not address topics such as chronic toxicity, solvent abuse, petrochemicals, or pesticides.
PMID: 11926609, UI: 21923569
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J R Soc Med 2002 Mar;95(3):151-3
RicBayliss@dial.pipex.com
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Med J Aust 2002 Feb 18;176(4):166-7
Turning Point Alcohol & Drug Centre, Fitzroy, VIC. nicoc@turningpoint.org.au
By diverting his dispensed medication, our patient collected 11 buprenorphine tablets (8 mg each), which he took in one day. The result was not respiratory depression, but instead severe opiate withdrawal lasting four days--this scenario has not previously been reported. This case highlights features of the unique pharmacology of buprenorphine and some key issues for its use in the management of heroin dependence.
PMID: 11913917, UI: 21910636
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