Am J Psychiatry 2002 Jun;159(6):1061-2
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PMID: 12042202, UI: 22037459
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Arch Dermatol 2002 Apr;138(4):546-7
PMID: 11939833, UI: 21937693
Arch Dermatol 2002 Apr;138(4):538-9
PMID: 11939827, UI: 21937687
Hum Exp Toxicol 2002 Jan;21(1):55-7
Emergency Department, Ondokuz Mayis University, Samsun, Turkey. zahidedoganay@yahoo.com
[Medline record in process]
Amitraz, a formamidine insecticide and acaricide used in veterinary practice, presents side effects in humans related to its pharmacological activity on alpha 2-adrenergic receptors. There is little information available in the literature about the toxicology of the product in man and the treatment of this poisoning. In this report, the clinical and laboratory features of amitraz poisoning in two patients by a veterinary formulation also containing xylene are presented. The major clinical findings were unconsciousness, drowsiness, respiratory failure requiring mechanical ventilation, miosis, hypothermia and bradycardia. The laboratory findings were hyperglycemia, hypertransaminasemia and increased urinary output. Supportive management of this poisoning in humans is suggested in only a few articles and there is no specific antidote for the subsequent possible pharmacological effects of amitraz. In our two cases, we performed supportive treatment such as mechanical ventilation, atropine, gastric lavage, active carbon, oxygen and fluid administration. We concluded that the basic approach to the patient with amitraz poisoning, including initial stabilization to correct immediate life-threatening problems, treatment to reduce absorption and measures to improve elimination of the toxin, is effective.
PMID: 12046725, UI: 22041653
Hum Exp Toxicol 2002 Jan;21(1):13-6
Department of Pediatrics, Faculty of Medicine, Selcuk University, Konya, Turkey. eatabek@selcuk.edu.tr
OBJECTIVE: To evaluate clinical experience of amitraz poisoning in children. METHODS: In this study, the clinical and laboratory features of amitraz poisoning in 14 children are presented and compared with previous studies. RESULTS: This study revealed that clinical manifestations of poisoning by oral and dermal routes appeared within 30-150 min, and that central nervous system (CNS) depression, which is the most important sign, improved within 6-24 hours and other signs within 24-72 hours. Unlike the findings in other studies, three severe cases in our study had reversible mydriasis and one of them required resuscitation because of cardiopulmonary arrest occurring as a result of serious respiratory depression. In addition, hepatic function test levels had increased in these three cases, and aspiration pneumonitis existed because of emesis in two of them. CONCLUSION: There is little information in the literature about dermal poisoning. The signs and symptoms of dermal poisoning were relatively mild compared with oral poisoning, and there were no topical signs. The classical signs of alpha2-adrenergic stimulation such as marked sinusal bradycardia and mydriasis as reported in many poisoning cases of animals have not been reported before our three severe cases among children.
PMID: 12046718, UI: 22041646
Lancet 2002 May 4;359(9317):1574
Hospital Hygiene, University Medical Center (W Popp MD) Hufelandstrasse 55, 45122, Essen, Germany
PMID: 12047968, UI: 22043545
MMWR Morb Mortal Wkly Rep 2002 May 17;51(19):414-6
As of May 15, 2002, a total of 13 presumptive cases of saxitoxin poisoning were reported in Florida residents who ate pufferfish caught in waters near Titusville, Florida. Five cases were reported in April, and eight cases were identified through increased surveillance by Florida poison control centers, hospital emergency departments (EDs), and county health departments. This report updates the investigation of these cases.
PMID: 12033478, UI: 22029390
Med J Aust 2002 Apr 15;176(8):403; discussion 403
PMID: 12041644, UI: 22036579
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