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Delayed onset of bullous reaction with severe deep skin necrosis in association with sertraline.
Kirkup ME, Sheffield EA, Sacks LJ, Sansom JE.
Publication Types:
PMID: 14746644 [PubMed - indexed for MEDLINE]
Comment on:
Lisinopril and Kaposi's sarcoma.
Di Carlo A.
Publication Types:
PMID: 14746638 [PubMed - indexed for MEDLINE]
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Allergic contact dermatitis to 5-aminolaevulinic acid methylester but not to 5-aminolaevulinic acid after photodynamic therapy.
Wulf HC, Philipsen P.
Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark. hcw01@bbh.hosp.dk
We report a patient with an allergy induced by photodynamic therapy (PDT) following simultaneous treatment with both 5-aminolaevulinic acid (ALA) and ALA methylester (ALA-ME). After several PDT treatments the patient presented with acute eczema of the treated areas and itch and hyper-reactivity of the untreated skin. Patch testing demonstrated a strong +++ reaction to ALA-ME only, indicating that derivatives common to ALA and ALA-ME were not involved. This is the first case of allergy to ALA-ME.
Publication Types:
PMID: 14746630 [PubMed - indexed for MEDLINE]
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Acute generalized exanthematous pustulosis associated with pseudoephedrine.
Padial MA, Alvarez-Ferreira J, Tapia B, Blanco R, Manas C, Blanca M, Bellon T.
Department of Allergy, Hospital Universitario La Paz, P degrees Castellana 261, 28046 Madrid, Spain.
Acute generalized exanthematous pustulosis (AGEP) is an uncommon skin disorder most often caused by drugs. Few adverse reactions to sympathomimetic drugs have been reported, despite their extensive use. Although the aetiology of AGEP remains uncertain, recent data have reported involvement of drug-specific T cells and interleukin (IL)-8 production. We characterized an adverse reaction to pseudoephedrine both clinically and immunologically. Histological analysis of skin biopsies confirmed the clinical entity as AGEP, while epicutaneous tests confirmed the specificity of the reaction to the drug. Moreover, immunohistochemical studies showed a mononuclear infiltrate consisting of activated memory T cells in addition to polymorphonuclear cells. Reverse transcription-polymerase chain reaction revealed an increased expression of IL-8 in AGEP-affected skin.
Publication Types:
PMID: 14746629 [PubMed - indexed for MEDLINE]
A rapid screening procedure for drugs and poisons in gastric contents by direct injection-HPLC analysis.
Politi L, Groppi A, Polettini A, Montagna M.
Department of Legal Medicine and Public Health, University of Pavia, Via Forlanini, 12 27100 Pavia, Italy.
A high performance liquid chromatographic method for toxicological drug screening of gastric content has been developed. The samples were diluted (1:3-1:30) in 0.01N hydrochloric acid and injected into a reverse phase column for separation by gradient elution. Mobile phase consisted of solvent A (acetonitrile/water 90:10, 0.01M sodium dodecylsulphate, 0.5% v/v glacial acetic acid) and solvent B (water/acetonitrile 90:10, 0.01M sodium dodecylsulphate, 0.5% v/v glacial acetic acid); the gradient was programmed from 20 to 80% A in 30min. The flow was kept constant at 1.5ml/min. Two home-made internal standards, butyrylsalicylic acid and diacetyltubocurarine with retention times of 5.6 and 21.4min, respectively, were used. Drugs are identified by matching their relative retention times and UV spectra (200-400nm) with those contained in a home made library of more than 340 reference compounds (9 analgesics, 22 antidepressants, 30 antihistamines, 14 antihypertensives, 21 antirheumatics, 15 beta-blockers, 9 bronchodilators, 10 Ca antagonists, 14 diuretics, 26 neuroleptics, 25 tranquilizers, and other significant xenobiotic compounds). The fluorometric (FLD) emission spectrum (280-700nm; excitation wavelength, 230nm) was used as a further identification. At 50mg/l analyte concentrations, the injection of gastric content after dilution (1:3) produced S/N ratios in the range 8-140. The method is simple, rapid, rather inexpensive and proved to be a useful means of investigation if used in combination with GC-MS screening in blood. On the other hand, the system suffers from a relatively limited sensitivity for compounds with a low UV absorption and from interferences due to the presence in the matrix of some highly UV- and FL-responsive compounds (e.g. tryptophan).
PMID: 15062949 [PubMed - in process]
Comment on:
Prevention of neurolathyrism during drought.
Lambein F, Kuo YH.
Publication Types:
PMID: 14987895 [PubMed - indexed for MEDLINE]
Comment on:
Prevention of neurolathyrism during drought.
Rao SL.
Publication Types:
PMID: 14987894 [PubMed - indexed for MEDLINE]
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