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Items 1 - 9 of 9 |
One page. |
Glasgow Coma Scale score and QTc interval in the prognosis of organophosphate poisoning.
Grmec S, Mally S, Klemen P.
Center for Emergency Medicine Maribor, Maribor, Slovenia.
OBJECTIVES: The aim of this study was to assess the applicability of the Glasgow Coma Scale (GCS) score and the Q-T interval corrected for heart rate (QTc interval) in predicting outcome and complications in patients with organophosphate (OP) poisoning. METHODS: This prospective, observational study included 65 patients older than 18 years. In the out-of-hospital setting, the end-tidal carbon dioxide (ETCO2), oxygen saturation (SaO2), QTc interval, and GCS score were monitored in each patient. A statistical comparison was then made between the group with respiratory failure and the group without this complication. RESULTS: The group with complications had significantly different values of measured parameters--a longer QTc interval and a lower GCS score, a higher number of intubations, and worse outcomes (p < 0.05). The two measures, GCS score and QTc interval, have been shown to be equally good in predicting respiratory failure and hospital mortality in patients with OP poisoning. CONCLUSIONS: In the initial out-of-hospital care of patients with OP poisoning, it is essential to monitor QTc interval and GCS score. These measures help with prognosis, and may suggest when to initiate precautions to prevent complications (i.e., respiratory failure). The simplicity and promptness of these methods allow providers to perform early and effective triage.
PMID: 15347541 [PubMed - in process]
C-reactive protein and serotonin syndrome.
leDoux M, Braslow K, Brown TM.
Publication Types:
PMID: 15285983 [PubMed - indexed for MEDLINE]
Evaluation of Lamotrigine Toxicity Reported to Poison Centers (November).
Lofton AL, Klein-Schwartz W.
Maryland Poison Center, School of Pharmacy, University of Maryland, Baltimore, MD.
BACKGROUND: Lamotrigine is an antiepileptic drug for the treatment of partial and generalized seizures as well as bipolar disorder. Limited published information exists describing the clinical effects of lamotrigine overdose. OBJECTIVE: To examine the toxicity of exposures to lamotrigine utilizing national poison center data. METHODS: Data on single-substance exposures to lamotrigine reported to the American Association of Poison Control Centers Toxic Exposure Surveillance System in 2000 and 2001 were retrospectively analyzed. RESULTS: There were 493 cases that met the inclusion criteria. The majority of exposures occurred within the age groups 20-59 years old (n = 198, 40.2%), followed by </=4 years old (n = 173, 35.1%). Overall, the majority of patients (52.1%) exposed to lamotrigine in overdose experienced no toxic clinical effects. The most common clinical effects reported in overdose were drowsiness/lethargy (20.9%), vomiting (11%), nausea (5.1%), ataxia (4.9%), dizziness/vertigo (4.5%), and tachycardia (4.3%). Major clinical effects included coma (n = 6), seizures (n = 8), and respiratory depression (n = 3). Medical outcome was reported as minor in 150 (30.4%), moderate in 73 (14.8%), and major in 13 (2.6%) cases. There were no deaths. CONCLUSIONS: These data demonstrate that the majority of patients exposed to lamotrigine in overdose experienced minor or no clinical effects. Although rare, serious effects can also occur.
PMID: 15353576 [PubMed - as supplied by publisher]
Cutaneous myiasis due to Dermatobia hominis.
Hohenstein EJ, Buechner SA.
Department of Dermatology, University of Basel, Kantonsspital Basel, Basel, Switzerland. ehohenstein@uhbs.ch
Cutaneous myiasis caused by the human botfly Dermatobia hominis involves the infestation of tissue with dipterous fly larvae and is common in the neotropical region of the New World. We report a case of D. hominis imported in Switzerland from Costa Rica. In the past, various approaches to extract the botfly larva have been reported. Copyright 2004 S. Karger AG, Basel
Publication Types:
PMID: 15118386 [PubMed - indexed for MEDLINE]
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Fixed drug eruption of the penis due to zolmitriptan.
Yesim B, Cem B.
Publication Types:
PMID: 15118377 [PubMed - indexed for MEDLINE]
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Photodistributed lichenoid drug eruption with rhabdomyolysis occurring during leflunomide therapy.
Rivarola de Gutierrez E, Abaca H.
Publication Types:
PMID: 15118375 [PubMed - indexed for MEDLINE]
Bullous skin eruption associated with entacapone.
Foti C, Cassano N, De Mari M, Sorino M, Vena GA.
Publication Types:
PMID: 15186236 [PubMed - indexed for MEDLINE]
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Celecoxib-induced photoallergic drug eruption.
Yazici AC, Baz K, Ikizoglu G, Kokturk A, Uzumlu H, Tataroglu C.
Departments of Dermatology and Pathology, Faculty of Medicine, Mersin University, 33079 Zeytinlibahce, Mersin, Turkey. aycacordan@yahoo.com
Photoallergic dermatitis is caused by a photosensitizing substance plus sunlight exposure in a sensitized person. If the photosensitizer is delivered internally, it is called a photoallergic drug reaction. Celecoxib is a new generation non-steroidal anti-inflammatory drug and sulfonamide derivative. We report a photoallergic drug eruption associated with the introduction of celecoxib. To our knowledge, this is the first report of photoallergic drug reaction associated with celecoxib.
Publication Types:
PMID: 15186233 [PubMed - indexed for MEDLINE]
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Bedbug bites: a review.
Thomas I, Kihiczak GG, Schwartz RA.
Dermatology, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103-2714, USA.
Publication Types:
PMID: 15186224 [PubMed - indexed for MEDLINE]
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