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Items 1 - 14 of 14 |
One page. |
[Erythema nodosum and adenopathy in a 15-year-old boy: uncommon signs of cat scratch disease]
[Article in French]
Sarret C, Barbier C, Faucher R, Lacombe P, Meyer M, Labbe A.
Service des urgences medicochirurgicales pediatriques, pediatrie A, Hotel-Dieu, CHU de Clermont-Ferrand, boulevard Charles-de-Gaulle, 63058 Clermont-Ferrand cedex 01, France.
Erythema nodosum rarely occurs in childhood and can be caused by cat scratch disease, as a result of agent Bartonella henselae. We report the case of a teenager who presented erythema nodosum and bilateral inguinal adenitis. Cat scratch disease diagnosis was confirmed by anti-Bartonella henselae serologies. Despite an appropriate antibiotic therapy, evolution was unfavourable with adenitis abcedation requiring surgical drainage. CONCLUSION: Erythema nodosum in children must let think to cat scratch disease among others etiologies.
Publication Types:
PMID: 15734128 [PubMed - indexed for MEDLINE]
Comment on:
Clomipramine and neuroleptic malignant syndrome: literature on adverse reactions to psychotropic drugs continues to confuse.
Isbister GK, Buckley NA.
Publication Types:
PMID: 15802729 [PubMed - indexed for MEDLINE]
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About an unusual case: GC-MS detection of lidocaine.
Teatino, Barbaro A.
Department of Toxicology, SIMEF-89128 Reggio Calabria, Italy. simef@tiscali.it
A man suspected to be a drug user was found dead; toxicological analysis of his biological samples showed the presence of lidocaine in all samples analysed, while cocaine was found only in the blood, urine and hair samples. We found that the cause of death was determined by ventricular arrhythmia associated to lidocaine/cocaine overdosage.
Publication Types:
PMID: 15724289 [PubMed - indexed for MEDLINE]
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Optimization of an analytical method for detecting paraphenylenediamine (PPD) by GC/MS-iontrap in biological liquids.
Stambouli A, Bellimam MA, El Karni N, Bouayoun T, El Bouri A.
Laboratory of Forensic Sciences of Moroccan Gendarmerie Royale, BP. 6597, Rabat Instituts, CP 10100 Rabat-Maroc, Morocco. labgr@menara.ma
A method for qualitative and quantitative determination of paraphenylenediamine in biological fluids (blood, urine and gastric content) was developed. This analytical procedure involves deproteneisation or hydrolysis, liquid-liquid extraction, derivatization with TFA followed by GC-MS iontrap analysis. Benzidine was the internal standard used for quantification and the extraction recovery test was about 85%. The detection limit of paraphenylenediamine was determined at 0.1 pg (S/N=10).
PMID: 15639598 [PubMed - indexed for MEDLINE]
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Illegal drugs-related fatalities in Slovenia.
Karlovsek MZ.
Medical Faculty, Institute for Forensic Medicine, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia. dekar@mf.uni-lj.si
The study includes 122 medico-legally examined fatal poisonings with illegal drugs in Slovenia (1.96 million inhabitants) in years 1997-2003. The highest death rate expressed per 10(5) inhabitants per year was observed in the year 2002 with 1.17, the average value over 1997-2003 was 0.89; the trend line shows a stabilisation. Heroine/morphine dominated as the cause of death and were responsible for 71.3% of the fatal poisonings. Methadone was found to cause or contributed to death in 28 cases (22.9%). One death by cocaine and two by MDMA were caused in the time observed. Males represent 98.4% of the direct illegal drug-related deaths. The main ages of heroine/morphine group, heroine/morphine only and methadone group were 27.6, 24.1 and 26.8, respectively. Between 1997 and 2003, there was a downward trend in the average age in the group heroine/morphine only. Since 2001, we are the part of the national working group on key indicator "drug-related mortality" applying EMCDDA methodology.
PMID: 15639594 [PubMed - indexed for MEDLINE]
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Diagnostic values of combined glucose and lactate values in cerebrospinal fluid and vitreous humour--our experiences.
Karlovsek MZ.
Institute for Forensic Medicine, Medical Faculty, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia. dekanat@mf.uni-lj.si
The final diagnosis of death in hypoglycaemic or diabetic coma should always be done as a synopsis of anamnestic response, morphology, biochemical (glucose, lactate, HBA1c, ketonic bodies, insulin, and C-peptide) and toxicological findings. High glucose levels in vitreous humour (more than 13 mmol/L, 234 mg/dL) or combined values of glucose and lactate in vitreous humour or in cerebrospinal fluid over threshold values of 23.7 mmol/L (427 mg/dL) and 23.4 mmol/L (422 mg/dL) respectively, can be an indicator of the pre-mortem hyperglycaemic state with fatal outcome. The determination of glycated haemoglobin, acetone and other ketone bodies improve the diagnostic values of the whole procedure. Diabetic ketoacidosis (blood acetone >0.3 g/L) is more often the cause of death of diabetic patients than the non-ketotic hyperosmolal state. Hypoglycaemia is deemed fatal if the combined values are lower than 5.5 mmol/L (100 mg/dL) and can not be excluded if they are lower than 8.9 mmol/L (160 mg/dL). Two cases of detected hypoglycaemia are described further. A psychiatric patient with diabetes (Hba1c 8.4%) committed suicide with an insulin overdose. The combined values of glucose and lactate in vitreous humour and in cerebrospinal fluid were 3.3 and 4.1 mmol/l, respectively. In another case a low combined glucose and lactate value (8.7 mmol/L) in vitreous humour indicated, besides the high concentration of glibenclamide (0.9 mg/L) in the blood of a driver with a poorly controlled diabetic condition (Hba1c = 10.6%), a state of decreasing blood glucose in the time before the accident causing the driver to feel un-well and behave inappropriately.
Publication Types:
PMID: 15639573 [PubMed - indexed for MEDLINE]
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Aniline and methanol toxicity after shoe dye ingestion.
Katz KD, Ruha AM, Curry SC.
Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, Arizona, USA.
A 39-year-old woman intentionally ingested Amberes shoe dye containing both methanol and aniline. She subsequently developed life-threatening methanol poisoning, methemoglobinemia, hemolytic anemia, and sulfhemoglobinemia. Treatment involved methylene blue infusion, emergent hemodialysis, fomepizole therapy, and blood products. Multiple toxicities can occur after ingestion of shoe dyes.
Publication Types:
PMID: 15498617 [PubMed - indexed for MEDLINE]
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Are 1 or 2 dangerous? Clozapine and olanzapine exposure in toddlers.
Wong DC, Curtis LA.
Department of Emergency Medicine, George Washington University, Washington, DC, USA.
Clozapine (Clozaril) and olanzapine (Zyprexa) are two relatively new atypical antipsychotics that are structurally and pharmacologically related. There are currently no therapeutic indications for these pharmaceuticals in infants and toddlers.Presumably, as the usage of these medications in adults increases, the frequency of unintentional pediatric ingestions will increase. In 2001 the annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System included a separate subcategory for atypical antipsychotics under the heading of sedatives/hypnotics/antipsychotics. The toxidrome resulting from these drugs is predominately central nervous system depression and anticholinergic effects. Although the desirable lack of extrapyramidal symptoms in adults results in their greatest clinical utility, several reports of toxic ingestions in small children are noteworthy for having extrapyramidal manifestations. We review here the available reported clinical experience with toxic doses of these medications that in small children may amount to as little as a single tablet. Although such doses may be lethal, supportive care and gastrointestinal decontamination in this population will generally lead to a good outcome.
Publication Types:
- Review
- Review of Reported Cases
PMID: 15388216 [PubMed - indexed for MEDLINE]
Blood mercury levels and neurobehavioral function.
Weil M, Bressler J, Parsons P, Bolla K, Glass T, Schwartz B.
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md, USA. mweil@jhsph.edu
CONTEXT: Due to its cardiovascular benefits, fish consumption is widely encouraged among older Americans. However, this fast-growing population is at increased risk of cognitive impairment and may be particularly sensitive to methylmercury, a neurotoxicant found in fish. OBJECTIVE: To describe associations of blood mercury levels with neurobehavioral test scores in an urban adult population. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional analysis to determine the effect of mercury levels on neurobehavior in 474 randomly selected participants in the Baltimore Memory Study, a longitudinal study of cognitive decline involving 1140 Baltimore residents aged 50 to 70 years. We measured total mercury in whole blood samples and used multiple linear regression to examine its associations with neurobehavioral test scores. First-visit data were obtained in 2001-2002. MAIN OUTCOME MEASURES: Twenty scores from 12 neurobehavioral tests. RESULTS: The median blood mercury level was 2.1 microg/L (range, 0-16 microg/L). After adjustment for covariates, increasing blood mercury was associated with worse performance on Rey complex figure delayed recall, a test of visual memory (beta, -0.224; 95% confidence interval, -0.402 to -0.047). However, increasing blood mercury levels were associated with better performance on finger tapping, a test of manual dexterity (beta for dominant hand, 0.351; 95% confidence interval, 0.017-0.686). CONCLUSION: Overall, the data do not provide strong evidence that blood mercury levels are associated with worse neurobehavioral performance in this population of older urban adults.
PMID: 15840862 [PubMed - indexed for MEDLINE]
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Doctor sues clinic over Yushchenko poisoning claims.
Holt E.
Publication Types:
PMID: 15841557 [PubMed - in process]
Comment on:
Prophylaxis against rabies.
Wilde H, Hemachudha T.
Publication Types:
PMID: 15832456 [PubMed - indexed for MEDLINE]
Comment on:
Prophylaxis against rabies.
Van den Enden E.
Publication Types:
PMID: 15832455 [PubMed - indexed for MEDLINE]
Comment on:
Prophylaxis against rabies.
Kurathong S.
Publication Types:
PMID: 15829548 [PubMed - indexed for MEDLINE]
Comment on:
Marathon maladies.
Levine BD, Thompson PD.
Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center at Dallas, USA.
Publication Types:
PMID: 15829532 [PubMed - indexed for MEDLINE]
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