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Efficacy of treatment with tetracyclines to prevent acneiform eruption secondary to cetuximab therapy.
Micantonio T, Fargnoli MC, Ricevuto E, Ficorella C, Marchetti P, Peris K.
Publication Types:
PMID: 16172328 [PubMed - indexed for MEDLINE]
Comment on:
Rosaceiform dermatitis as a complication of treatment of facial seborrheic dermatitis with 1% pimecrolimus cream.
Gorman CR, White SW.
Publication Types:
PMID: 16172323 [PubMed - indexed for MEDLINE]
Comment on:
Do get in touch.
Hatcher S, Owens D.
Publication Types:
PMID: 16210256 [PubMed - indexed for MEDLINE]
Ethylene glycol poisoning.
Leth PM, Gregersen M.
Institute of Forensic Medicine, University of Southern Denmark, Faculty of Health Sciences, Winslovparken 17, DK-5000 Odense C, Denmark.
Ethylene glycol (EG) can be found in many agents, such as antifreeze. Ingestion of EG may cause serious poisoning. Adults are typically exposed when EG is ingested as a cheap substitute for ethanol or in suicide-attempts. Children may be exposed by accidental ingestion caused by decantation of EG to unlabeled bottles. EG has in itself a low toxicity, but is in vivo broken down to four organic acids: glycoaldehyde, glycolic acid, glyoxylic acid and oxalic acid. The metabolites are cell toxins that cause central nervous system depression, and cardio-pulmonary and renal failure. Glycolic acid causes severe acidosis, and oxalate is precipitated as calcium oxalate in the kidneys and other tissues. We present five case reports of fatal EG-poisoning, and review the literature concerning clinical presentation and diagnosis, pathological findings, treatment and prevention.
PMID: 16226155 [PubMed - in process]
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Suspected clozapine poisoning in the UK/Eire, 1992-2003.
Flanagan RJ, Spencer EP, Morgan PE, Barnes TR, Dunk L.
Medical Toxicology Unit, Guy's and St Thomas' NHS Foundation Trust, Avonley Road, London SE14 5ER, UK.
OBJECTIVE:: Toxicological analyses are often performed to investigate suspected poisoning, but the interpretation of results may not be straightforward. We studied suspected poisoning cases 1992-2003 where blood clozapine and N-desmethylclozapine (norclozapine) were measured in order to assess the relationship of these parameters to outcome. METHODS:: Samples were referred from clinicians, pathologists/coroners, or via the Clozaril Patient Monitoring Service (CPMS, Novartis). Information was gathered from clinical, post-mortem, or coroners' reports. RESULTS:: There were seven fatal [five male, two female; median (range) age 28 (24-41) year] and five non-fatal [four male, one female; median age 35 (26-41) year] clozapine overdoses. The median post-mortem blood clozapine and norclozapine concentrations were 8.2 (3.7-12) and 1.9 (1.4-2.4)mg/L, respectively [median clozapine:norclozapine ratio 4.4 (2.9-5.1)]. The median plasma clozapine and norclozapine concentrations (first or only sample) were 3.9 (1.7-7.0) and 0.40 (0.30-0.70)mg/L, respectively [median clozapine:norclozapine ratio 7.6 (5.3-18)] in the remainder. These overdoses were in patients who were poorly or non-adherent to clozapine, or who had taken tablets prescribed for someone else. In 54 further people who died whilst receiving clozapine [38 male, 16 female; median age 41 (22-70) year], the median post-mortem blood clozapine and norclozapine concentrations were 1.9 (0-7.7, n=43) and 1.4 (0-6.0, n=39)mg/L, respectively [median clozapine:norclozapine ratio 1.5 (0.4-7.6, n=38)]. The median post-mortem increase in blood clozapine and norclozapine as compared to the most recent ante-mortem measurement was 489 (98-5350)% and 371 (139-831)%, respectively [median sample time before death 14 (0-30, n=21) days]. CONCLUSION:: Clozapine poisoning cannot be diagnosed on the basis of blood clozapine and norclozapine concentrations alone. The analysis of ante-mortem blood specimens collected originally for white cell count monitoring and the blood clozapine:norclozapine ratio may provide additional interpretative information.
PMID: 16226146 [PubMed - as supplied by publisher]
General scenario of poisoning and its pattern in India.
Panthee S.
Publication Types:
PMID: 16235739 [PubMed - in process]
Deliberate self-poisoning in Ontario following the terrorist attacks of September 11, 2001.
Detsky ME, Sivilotti ML, Kopp A, Austin PC, Juurlink DN.
Publication Types:
PMID: 16234495 [PubMed - indexed for MEDLINE]
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Food poisoning cases must be handled with care.
[No authors listed]
Publication Types:
PMID: 16226593 [PubMed - in process]
Comment on:
Gamma-hydroxybutyric acid.
Zvosec DL, Smith SW.
Publication Types:
PMID: 16224826 [PubMed - indexed for MEDLINE]
Comment on:
Gamma-hydroxybutyric acid.
Sass JO, Superti-Furga A.
Publication Types:
PMID: 16221793 [PubMed - indexed for MEDLINE]
Envenomation by the Northern Blacktail Rattlesnake (Crotalus molossus molossus): case report.
Yarema MC, Curry SC.
Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, AZ 85006, USA. Mark.Yarema@bannerhealth.com
The clinical course after a human envenomation by the Northern Blacktail rattlesnake (Crotalus molossus molossus) is not well described in the literature. The present report discusses a 12-year-old girl who was envenomated by C. molossus molossus and treated with antivenom (Crotalidae polyvalent immune Fab). Her recovery was uncomplicated, and she was discharged after 48 hours of hospitalization. Hematologic and coagulation studies were within normal limits at follow up. The clinical effects of C. molossus molossus envenomation are reviewed, and previous reports of bites by C. molossus molossus are discussed and compared with our patient.
PMID: 15643324 [PubMed - indexed for MEDLINE]
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