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Am J Emerg Med 2002 Nov;20(7):588-94
Division of Cardiology, Sahlgrenska University Hospital, Goteborg, Sweden, and dagger The Rescue Service, Goteborg, Sweden.
[Medline record in process]
The purpose of this study was to evaluate the possibility to predict in the prehospital phase the occurrence of a life-threatening disease or death among ambulance transported patients with acute chest pain or other symptoms raising any suspicion of an acute coronary syndrome. All patients transported by ambulance during 3 months in the community of Goteborg because of symptoms raising any suspicion of an acute coronary syndrome were included in the study. In all, 930 transports (of 859 patients) fulfilled the inclusion criteria, of which 235 (25.3%) fulfilled the critera for a life-threatening disease. The overall 30-day mortality was 8.8%, and the 1-year mortality was 18.0%. Independent predictors for a life-threatening disease were a low oxygen saturation on admission of the ambulance crew, patient being clammy on admission of the ambulance crew, a history of myocardial infarction and ST elevation and T-wave inversion on admission to the emergency department. Independent predictors for 30-day mortality were age greater than 70 years, symptoms of dyspnoea, a low oxygen saturation, hypotension and decreased consciousness on admission of the ambulance crew, and ST-depression on electrocardiogram (ECG) on admission to the emergency department. Predictors of 1 year mortality were age greater than 70 years, a history of myocardial infarction, symptoms of dyspnoea, a low oxygen saturation on admisson of the ambulance crew and ST-depression, and no sinus rhythm on admission to the emergency department. Among patients with acute chest pain or other symptoms raising any suspicion of an acute coronary syndrome, factors associated with a life-threatening disease and death could be defined. Predictors for the risk of death during the first 30 days were age greater than 70 years, symptoms of dyspnoea, a low oxygen saturation, hypotension and decreased consciousness on admission of the ambulance crew, and ST-depression on ECG on admission to the emergency department. (Am J Emerg Med 2002;20:588-594. Copyright 2002, Elsevier Science (USA). All rights reserved.)
PMID: 12442235, UI: 22328499
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Clin J Pain 2002 Nov-Dec;18(6):394-401
OBJECTIVE The aim of this study was to examine childhood traumatic experiences and dissociative characteristics in women with chronic headache and low back pain.SETTING The patients were evaluated in the multidisciplinary pain clinic of a university hospital.SUBJECTS This study included 73 patients: 41 with chronic headache and 32 with chronic low back pain.OUTCOME MEASURES All the patients were assessed with use of a semistructured questionnaire, the Dissociative Experiences Scale (DES), the Somatoform Dissociation Questionnaire (SDQ), and the Childhood Abuse and Neglect Questionnaire.RESULTS AND CONCLUSIONS There were no significant differences between the headache and low back pain groups in terms of prevalence of history of neglect; abuse; or sexual, physical, and emotional abuse separately. In addition, no significant differences were found between the groups with respect to the Dissociative Experiences Scale scores. However, analysis of the SDQ scores showed that the neglect rate in the two groups differed significantly. According to our findings, the neglect rate was higher in the headache group, thus warranting further research to investigate the sensitivity of the SDQ for neglect.
PMID: 12441834, UI: 22328810
Clin J Pain 2002 Nov-Dec;18(6):386-93
OBJECTIVE To test whether muscle pain intensity caused by different intensities of unaccustomed eccentric exercise was moderately and negatively associated with resting blood pressure, and whether women reported higher pain ratings compared with men in response to such exercise.DESIGN AND SUBJECTS The repeated measures design involved random assignment of 42 young adults (21 women, 7 per condition) to complete elbow extension exercises with a weight that was 80%, 100%, or 120% of their maximal voluntary concentric strength. Total work was equated by manipulating the number of repetitions performed in the 80% (n = 45), 100% (n = 36), and 120% (n = 30) condition groups.SETTING A clinical laboratory in a large university in the southeastern U.S.OUTCOME MEASURES Pain intensity ratings averaged over 3 days and resting blood pressure measurements averaged over 6 days.RESULTS For both sexes there was a dose-response relation between the relative intensity of the unaccustomed eccentric exercise and mean pain intensity ratings. Mean pain intensity was not significantly related to systolic or diastolic blood pressure. There was no significant sex difference in pain intensity, although men's ratings, in contrast to expectations, tended to be higher than the women's ratings.CONCLUSIONS The negative findings, contrary to those predicted from previous experiments in which other types of noxious stimuli have been used, suggest that sex and blood pressure associations with pain intensity are stimulus dependent.
PMID: 12441833, UI: 22328809
Clin J Pain 2002 Nov-Dec;18(6):380-5
OBJECTIVES To report preliminary data relevant to the effects of an exercise and toileting intervention on pain among incontinent nursing home (NH) residents.DESIGN A randomized controlled intervention trial.SETTING AND PARTICIPANTS Fifty-one incontinent residents in one skilled NH.INTERVENTION The intervention was implemented by research staff for a total of 4 times a day (every 2 hours), 5 days a week, for 32 weeks. Residents were provided with incontinence care and assistance to either walk or, if nonambulatory, wheel their chairs, and to repeat sit-to-stand movements.MEASUREMENTS Pain was measured in two ways at baseline and again at 32 weeks: (1) a count of the number of verbal expressions and pain behaviors during a standardized physical performance assessment; and (2) a modified Geriatric Pain Measure administered in a one-on-one interview format.RESULTS There were significant differences between intervention and control groups on all physical performance measures over time, with the intervention group remaining stable and the control group showing a significant decline in sit-to-stand, walking, and wheelchair propulsion endurance. Both groups showed mild to moderate pain at baseline according to each of the two pain measures, while there were no significant changes in pain reports between groups over time based on either measure. There was, however, a trend for pain to increase in the intervention group.CONCLUSIONS No significant changes in pain reports were attributable to exercise despite significant improvements in physical performance. In fact, there was a tendency for pain reports to increase with exercise. These preliminary findings suggest that exercise alone may be ineffective for pain management among incontinent NH residents. Care providers should consider that exercise to improve physical function may increase pain symptoms, requiring preemptive analgesia, other pain control strategies, or modified exercise techniques for this frail segment of the NH population.
PMID: 12441832, UI: 22328808
Clin J Pain 2002 Nov-Dec;18(6):373-9
Department of Anesthesiology, School of Medicine, University of California, San Diego, La Jolla, USA. mswallace@ucsd.edu
OBJECTIVE: The predelivery of intravenous alfentanil (a mu opioid agonist) and ketamine (an -methyl d-aspartate antagonist) has recently been shown to decrease the secondary hyperalgesia induced by intradermal capsaicin. The focus of this study was to determine the effects of the postdelivery of intravenous alfentanil and ketamine on intradermal capsaicin-induced secondary hyperalgesia. DESIGN: Double-blind, placebo-controlled, randomized, crossover study. Five minutes after an intradermal capsaicin injection, alfentanil and ketamine infusions were administered for a target plasma concentration of 75 ng/ml for alfentanil and 150 ng/ml for ketamine or placebo equivalent using a computer-controlled infusion pump and maintained for the remainder of the study. The investigator recorded the magnitude of the pain score at the time of injection and at 5-minute intervals. Fifteen minutes after the intradermal capsaicin injection, the region of secondary hyperalgesia and flare response was determined. RESULTS: Alfentanil and ketamine plasma levels targeted after injection of intradermal capsaicin had no significant effect on pain scores, flare response, or secondary hyperalgesia. CONCLUSIONS: Consistent with animal studies on preemptive analgesia, this study demonstrates that alfentanil and ketamine have a differential effect when delivered before and after a painful stimulus. Because of the differential effect seen, future studies on the pharmacology of human experimental pain should evaluate both predrug and postdrug delivery.
PMID: 12441831, UI: 22328807
Clin J Pain 2002 Nov-Dec;18(6):366-72
BACKGROUND Pharmacoeconomic analysis is increasingly being used to assist decision makers in getting the biggest "bang for the buck" within cost-constrained health care budgets. The tools and techniques of this science, however, have scarcely been applied to neuropathic pain.OBJECTIVE To describe the basic principles of pharmacoeconomic analysis and set forth a preliminary pharmacoeconomic model of neuropathic pain.KEY FINDINGS Applying the tools and techniques of pharmacoeconomic analysis to neuropathic pain yields several insights. First, because pain treatment predominantly benefits quality of life, the results of a pharmacoeconomic analysis of neuropathic pain treatment should be expressed in terms of the cost per quality-adjusted life-year (QALY)-gained metric. Second, because pain can fluctuate, a state-transition modeling approach should be used in constructing the pharmacoeconomic model to account for changes in pain status over time, particularly as relates to the effects of treatment. Finally, assessment of typical practice patterns in neuropathic pain suggests that the pharmacoeconomic model should account for multiple rounds of treatment (i.e., first-line therapy, second-line therapy, and so on), primary care to specialty care referral patterns, and differences in costs and outcomes between primary care physicians and pain specialists.CONCLUSIONS Pharmacoeconomic analysis of neuropathic pain treatments can play an influential role in formulary committee deliberations, treatment algorithms, and decision making in the clinical setting. By describing the fundamental concepts and key challenges in this field, it is hoped that this article will represent a useful first step toward a pharmacoeconomic model of neuropathic pain.
PMID: 12441830, UI: 22328806
Clin J Pain 2002 Nov-Dec;18(6):355-65
OBJECTIVE Chronic pain is a prevalent and costly problem. This review addresses the question of the clinical effectiveness and cost-effectiveness of the most common treatments for patients with chronic pain.DATA SOURCES Representative published studies that evaluate the clinical effectiveness of pharmacological treatments, conservative (standard) care, surgery, spinal cord stimulators, implantable drug delivery systems (IDDSs), and pain rehabilitation programs (PRPs) are examined and compared. The cost-effectiveness of these treatment approaches is also considered.DATA SYNTHESIS Outcome criteria including pain reduction, medication use, health care consumption, functional activities, and closure of disability compensation cases are examined. In addition to clinical effectiveness, the cost-effectiveness of PRPs, conservative care, surgery, spinal cord stimulators, and IDDSs are compared using costs to return a treated patient to work to illustrate the relative expenses for each of these treatments.CONCLUSIONS There are limitations to the success of all the available treatments. The author urges caution in interpreting the results, particularly in comparisons between treatments and across studies, because there are broad differences in the pain syndromes and inclusion criteria used, the drug dosages, comparability of treatments, the definition of "chronic" used, the outcome criteria selected to determine success, and societal differences. None of the currently available treatments eliminates pain for the majority of patients. Pain rehabilitation programs provide comparable reduction in pain to alternative pain treatment modalities, but with significantly better outcomes for medication use, health care utilization, functional activities, return to work, closure of disability claims, and with substantially fewer iatrogenic consequences and adverse events. Surgery, spinal cord stimulators, and IDDSs appear to have substantial benefits on some outcome criteria for carefully selected patients. These modalities are, however, expensive. Pain rehabilitation programs are significantly more cost effective than implantation of spinal cord stimulators, IDDSs, conservative care, and surgery, even for selected patients. Research is needed to identify which patients are most likely to benefit from the available treatments and to study combinations of the available treatments since none of them appear capable of eliminating pain or significantly improving functional outcomes for all treated.
PMID: 12441829, UI: 22328805
Clin J Pain 2002 Nov-Dec;18(6):350-4
OBJECTIVE This article reviews the prevalence, risk factors, natural history, and impact on quality of life of painful diabetic neuropathy (PDN) and postherpetic neuralgia (PHN).DISCUSSION Diabetes mellitus afflicts more than 14 million persons in the U.S. An estimated 20% to 24% of these persons experience PDN. Data on risk factors for PDN are limited, but duration of diabetes mellitus and poor glycemic control are probably important factors. Painful diabetic neuropathy may interfere with general activity, mood, mobility, work, social relations, sleep, leisure activities, and enjoyment of life. Herpes zoster strikes an estimated 800,000 persons each year in the U.S., most of whom are elderly or immunosuppressed. Using pain at 3 months after rash onset as a definition of PHN, between 25% and 50% of adults older than 50 years develop PHN, depending on early antiviral therapy for herpes zoster. Increasing age, greater pain and rash severity, greater degree of sensory impairment, and psychological distress are risk factors for PHN. Postherpetic neuralgia may cause fatigue, insomnia, depression, anxiety, interference with social roles and leisure activity, and impaired basic and instrumental activities of daily living.CONCLUSIONS Both conditions are common complications of their underlying disorders and can profoundly diminish the quality of life of affected persons.
PMID: 12441828, UI: 22328804
Clin J Pain 2002 Nov-Dec;18(6):343-9
OBJECTIVE An overview is presented of neuropathic pain syndromes, their characteristic symptoms and signs, and recent approaches to identifying their pathophysiologic mechanisms.DESIGN The results of recent clinical studies of neuropathic pain are reviewed. Chronic neuropathic pain syndromes are emphasized because these long-lasting and often disabling conditions present a much greater challenge for the clinician than acute pain. Peripheral neuropathic syndromes have received greater attention in the research literature than central pain, and studies of syndromes such as postherpetic neuralgia and painful diabetic neuropathy provide the basis for current knowledge of neuropathic pain.CONCLUSIONS Precise estimates of the prevalence of neuropathic pain are not available, but chronic neuropathic pain may be much more common than has generally been appreciated and its prevalence can be expected to increase in the future. There is considerable agreement that both peripheral and central processes contribute to many chronic neuropathic pain syndromes, and that these different mechanisms may explain the qualitatively different symptoms and signs that patients experience. The limitations of existing treatments for neuropathic pain and the inability to provide relief for many patients has stimulated ongoing studies that examine different approaches to preventing neuropathic pain.
PMID: 12441827, UI: 22328803
Pain 2002 Nov;100(1-2):203-9
Department of Pharmacology, School of Medicine, Gulhane Military Medical Academy, 06018, Etlik, Ankara, Turkey
Recent studies demonstrate the possible existence of tonic modulatory control of nociceptive input mediated by spinal cannabinoid receptors (CB1). Accordingly, it is predicted that a reduction in the spinal CB1 receptors may enhance sensitivity to sensory stimuli and a decrease in spinal antinociceptive potency to cannabinoid agonists. An antisense oligodeoxynucleotide (ODN) specific to the CB1 receptor was used to 'knock-down' CB1 receptors in the lumbar spinal cord and dorsal root ganglia by the local, repeated intrathecal (i.th.) administration of the ODN. This treatment resulted in a decrease in lumbar spinal CB1 receptor expression accompanied by a decrease in the response thresholds to both innocuous tactile and noxious thermal stimuli. The antinociceptive action of the CB1 agonist, WIN 55,212-2, by i.th. administration was also significantly attenuated after treatment with the antisense ODN. Similar treatment using a mismatch control ODN had no effect on receptor protein or on sensory thresholds. The effects of the antisense ODN treatment on sensory thresholds were fully reversed after discontinuation of the ODN injection. The antisense ODN treated rats also showed a significant increase in lumbar spinal dynorphin A. Acute i.th. injection of MK-801 or an antidynorphin antiserum blocked the antisense ODN-induced tactile and thermal hypersensitivity. These data support the possibility of endogenous inhibitory cannabinoid tone to limit spinal afferent input of thermal and tactile stimuli. Lifting of this inhibitory tone through a 'knock-down' of spinal CB1 receptors apparently lowers the thresholds for sensory input, as reflected by the actions of MK-801 to block tactile and thermal hypersensitivity. The increased spinal dynorphin may act to further promote afferent outflow and abnormal pain because sequestration of spinal dynorphin with antiserum also reverses the manifestations of abnormal pain following knock-down of CB1 receptors.
PMID: 12435473, UI: 22323670
Pain 2002 Nov;100(1-2):191-201
Department of Anesthesiology, Vanderbilt University School of Medicine, 37212, Nashville, TN, USA
Resting blood pressure is inversely correlated with acute pain sensitivity in healthy normotensives. This study tested: (1) whether endogenous opioid activity is necessary for this adaptive relationship to occur, (2) whether this relationship is altered in chronic low back pain (LBP), and (3) whether endogenous opioid dysfunction underlies any such alterations. Fifty-one pain-free normotensives and 44 normotensive chronic LBP sufferers received opioid blockade (8mg naloxone i.v.) or placebo blockade (saline) in randomized, counterbalanced order in separate sessions. During each session, subjects participated in a 1-min finger pressure (FP) pain task followed by an ischemic (ISC) forearm pain task. Among pain-free normotensives, elevated resting systolic (SBP) and diastolic (DBP) blood pressure were associated with significantly higher ISC pain thresholds (P values <0.05). Elevated SBP was also associated with significantly lower FP pain ratings (P<0.05). Opioid blockade had no significant effect on the BP-pain relationships detected (P values >0.10). In combined groups analyses, a significant subject typexSBP interaction (P<0.005) was found on ISC pain threshold: elevated SBP was associated with higher pain threshold in pain-free controls, but with lower pain threshold in LBP subjects. Although subject typexBP interactions on FP and ISC pain ratings were not significant, inclusion of LBP subjects in these analyses resulted in the overall relationship between BP and pain sensitivity becoming positive (P values <0.05). Opioid blockade exerted no significant main or interaction effects in these combined groups analyses (p values >0.10). Higher DBP was associated with greater clinical pain intensity among the LBP subjects (P<0.001). Overall, these results suggest: (1) endogenous opioids do not mediate the inverse relationship between resting blood pressure and acute pain sensitivity in pain-free normotensives; (2) the BP-pain sensitivity relationship is altered in chronic pain, suggesting dysfunction in pain regulatory systems, and (3) these alterations are not related to opioid dysfunction.
PMID: 12435472, UI: 22323669
Pain 2002 Nov;100(1-2):163-70
Department of Pharmacology, Dartmouth Medical School, 03756, Hanover, NH, USA
The present study was undertaken to determine whether leukocytes are recruited into the spinal cord following a peripheral L5 spinal nerve transection that results in mechanical allodynia (increased tactile sensitivity behavior correlates with neuropathic pain). In rats subjected to bone marrow irradiation, donor-specific major histocompatibility complex (MHC) class I (I1-69) positive peripheral immune cells trafficked to the L5 spinal cord in response to an L5 spinal nerve injury. The number of I1-69 positive cell profiles increased over time and correlated with increased mechanical allodynia. At early time points following injury, I1-69 positive immune cells co-regionalized with the expression of the macrophage marker ED2. At later time points following injury, some of the infiltrating immune cells did not co-regionalize with the macrophage marker ED2. At no time did the infiltrating cells co-regionalize with the neuronal marker (NeuN). Both macrophage-like morphology and T cell-like morphology were observed in the I1-69 positive cellular infiltrate. Conversely, animals that underwent sham surgery demonstrated little mechanical allodynia and a minimal number of infiltrating peripheral immune cells. In a separate group of rats, infiltration of CD3+ T-lymphocytes was confirmed at 14 days post-nerve transection. This study demonstrates trafficking of leukocytes into the lumbar spinal cord at time points that correlate with mechanical allodynia suggesting a role of central neuroinflammation in persistent neuropathic pain.
PMID: 12435469, UI: 22323666
Pain 2002 Nov;100(1-2):155-62
Anesthesiology Pain Research Group, Department of Anesthesiology, Centre Hospitalier Universitaire Vaudois (CHUV), 1011, Lausanne, Switzerland
Neuropathic pain syndromes are characterized by spontaneous pain and by stimulus-evoked allodynia and hyperalgesia. Stimulus-induced pain, i.e. the capacity of external stimuli to alter sensory processing so as to generate a pain hypersensitivity that outlasts the initiating stimulus, is usually present only after intense activation of nociceptors. In abnormal pain states, however, such as after capsaicin injection or inflammation, a stimulus-induced incremental pain can be generated by repetitive light touch, termed progressive tactile hypersensitivity (PTH). In the present study, we have examined whether PTH also occurs in two experimental models of neuropathic pain: a crush injury of the sciatic nerve and the spared nerve injury (SNI) model. When applied during the first weeks after injury to the territory of the injured crushed nerve, repeated low-intensity mechanical stimulation did not change the mechanical withdrawal threshold response. However, 10 weeks and after, the same repeated stimulation induced a progressive tactile hypersensitivity that persisted after discontinuation of the tactile stimulation. Following SNI, repeated stimulation of the hypersensitive skin territory, corresponding to the intact spared sural nerve, never induced PTH. Tactile stimulation of regenerating afferents but not spared non-injured afferents, can induce, therefore, PTH and such a stimulus-induced alteration in pain processing may contribute to clinical neuropathic pain.
PMID: 12435468, UI: 22323665
Pain 2002 Nov;100(1-2):131-9
University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 183 S. Orange Ave., BHSB F-1512, 07103, Newark, NJ, USA
A purported pathogenic mechanism for the development of fibromyalgia, a medically unexplained syndrome involving widespread pain, is stress and associated psychiatric disorder. The major stressor of recent World Trade Center terrorist attacks provides a natural experiment for evaluating this mechanism. This study sought to determine whether symptoms consistent with fibromyalgia increased post-September 11 and whether exposure to specific terrorism-related events or prior depression predicted symptom increase. In a large community sample of women in the New York/New Jersey metropolitan area (n=1312), a cohort initially surveyed for pain and psychiatric symptoms before September 11th were recontacted approximately 6 months after the attacks to assess current symptoms and specific terrorism-related exposures. 'Fibromyalgia-like' (FM-L) four-quadrant pain reports consistent with a diagnosis of fibromyalgia were compared at baseline and follow-up. Result showed that FM-L rates did not increase significantly between baseline and post-attack follow-up. Event exposure did not relate to FM-L onset at follow-up, nor did depressive symptoms at baseline interact with event exposure. Depressive symptoms did not predict new onsets better than the extent of their comorbidity with FM-L at baseline. The failure to detect a significant increase in symptoms consistent with a diagnosis of fibromyalgia and the failure of new onsets of such symptoms to be accounted for by exposure to major stressors or prior depressive symptoms suggests that these hypothesized risk factors are unlikely to be of major importance in the pathogenesis of fibromyalgia.
PMID: 12435466, UI: 22323663
Pain 2002 Nov;100(1-2):119-30
Division of Public Health Services and Research, College of Dentistry, University of Florida, P.O. Box 100404, Gainesville, FL, USA
The purpose of this study was to describe race/ethnic differences in the use of formal health care services for painful oral symptoms by older adults. We also considered the sex of the respondent rather than assuming that males and females within a specific racial group would use health care services similarly. To our knowledge, these specific utilization patterns have never been reported before in the pain literature.Telephone interviews were conducted on a stratified random sample of 1636 community dwelling older (65+) north Floridians. A total of 5860 households were contacted and screened, with 75.3% participating to the point where their eligibility for the study could be determined.Overall race/ethnic differences in patterns of health care use for orofacial pain were not found. However, when we stratified race/ethnicity by sex, Black females (37.6%) were the least likely to have visited a health care provider, followed by non-Hispanic White females (47.2%), non-Hispanic White males (49.3%), and Black males (62.7%). Point estimates of odds ratio, adjusting for financial differences, indicate that more non-Hispanic White males (OR=1.79) and Black males (OR=2.74) visited a health care provider than Black females.Our results also suggest that for older Black adults, financial constraints have a more significant impact on decisions about health care for orofacial pain than they do for non-Hispanic Whites. For non-Hispanic White respondents, characteristics of the pain symptoms were significant determinates of health care use for their painful oral symptoms. Pain at its worst was a positive predictor for four of the five analyses (jaw joint pain, painful oral sores, temperature sensitivity, and toothache pain). The duration variable (years with pain) was a negative predictor of health care use. This is consistent with the conclusion that individuals seek care early in the course of the symptom, i.e. an active care seeking phase, make emotional or physical adjustments, and then resign themselves to the symptoms.
PMID: 12435465, UI: 22323662
Pain 2002 Nov;100(1-2):111-8
Department of Psychology and Educational Sciences, Ghent University, Henri Dunantlaan 2, 9000, Ghent, Belgium
This paper reports an experimental investigation of engagement with and disengagement from a threatening cue of pain. As most paradigms in pain research only provide an overall index of attentional deployment by pain-related information, a new paradigm was developed that allowed an independent investigation of engagement with and disengagement from pain cues. Forty pain-free volunteers performed a cueing task in which they had to detect pain targets and tone targets as quickly and as accurately as possible. The target stimuli were preceded by pain cues (the word 'pain'), tone cues (the word 'tone'), or neutral cues (a series of the character 'X') at stimulus onset asynchrony (SOA: stimulus interval between cue onset and target onset) levels of 100, 500, or 900ms. There was no contingency between the type of cue and the type of target. Catastrophic thinking about pain and the predictive value of the cues were assessed by self-reports. Results can be summarized as follows: When a cue correctly primed a target, attention was optimally engaged in the identification of the target irrespective of the threatening context of the cue or target. However, when pain was cued and did not occur, there was retardation in disengagement from the pain cue. This retardation was more pronounced and extended across time in those high in catastrophic thinking about pain. On examination it appeared that catastrophic thinking about pain may operate by a protection of the belief that the cue for pain is a valid one, despite experience to the contrary.
PMID: 12435464, UI: 22323661
Pain 2002 Nov;100(1-2):99-110
Dental Research Center, School of Dentistry, Medical Research Building A, University of North Carolina, CB #7175, 27599-7455, Chapel Hill, NC, USA
The current study examined patients with temporomandibular disorders (TMD) (n=20) and pain-free controls (n=28) under stress and relaxation conditions. Interleukin-6 (IL-6), norepinephrine and epinephrine (NE and E) were measured both before and during each of two conditions: a non-stressful relaxation period and a speech stressor. Ischemic pain sensitivity was also assessed after each of these conditions. Optimism (Life Orientation Test (LOT)), which has been associated with better outcomes in relationship to health and disease, was also evaluated in relationship to ischemic pain tolerance and unpleasantness ratings as well as to IL-6 levels under the two conditions. Regression analysis determined the unique contribution of each predictor and the interaction between Optimism and Group (TMD versus controls) after controlling for gender and blood pressure. During stress, IL-6 levels appeared to parallel NE with only controls displaying significant increases. After controlling for depressed mood, TMD patients as a whole showed a significantly blunted response in IL-6 levels produced during stress as compared to controls (beta=0.31*). Although TMD subjects as a whole did not show the expected greater pain sensitivity to the ischemic task, those displaying a less optimistic style did exhibit lower pain tolerance times (beta=-0.61*) and higher pain unpleasantness ratings (beta=0.48*), compared with low optimism controls and high optimism TMD patients. Less optimistic TMD patients also had higher NE and IL-6 levels during stress than other TMD patients, while optimism was unrelated to responses in controls (*P<0.05).
PMID: 12435463, UI: 22323660
Pain 2002 Nov;100(1-2):77-89
Department of Anesthesiology, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Hokkaido, Japan
In order to try to gain a better understanding of the mechanisms of post-operative pain, this study was designed to psychophysically determine physiological and pharmacological characteristics of experimental pain induced by a 4-mm-long incision through the skin, fascia and muscle in the volar forearm of humans. In experiment 1, the subjects (n=8) were administered lidocaine systemically (a bolus injection of 2mg/kg for a period of 5min followed by an intravenous infusion of 2mg/kg/h for another 40min), and then the incision was made. In experiment 2, cumulative doses of lidocaine (0.5-2mg/kg) were systemically injected in the subjects (n=8) 30min after the incision had been made, when primary and secondary hyperalgesia had fully developed. Spontaneous pain was assessed using the visual analog scale (VAS). Primary hyperalgesia was defined as mechanical pain thresholds to von Frey hair stimuli (from 7 to 151mN) in the injured area. The area of secondary hyperalgesia to punctate mechanical stimuli was assessed using a rigid von Frey hair (151mN). Flare formation was assessed in the first experiment using a laser doppler imager (LDI).Pain perception was maximal when the incision was made and then rapidly disappeared within 30min after the incision had been made. Primary hyperalgesia was apparent at 15min after the incision had been made and remained for 2 days. The incision resulted in a relatively large area of flare formation immediately after the incision had been made. The area of flare began to shrink within 15min and was limited to a small area around the injured area at 30min after incision. Secondary hyperalgesia was apparent at 30min after incision and persisted for 3h after incision and then gradually disappeared over the next 3h. In experiment 1, pre-traumatic treatment with systemic lidocaine suppressed primary hyperalgesia only during the first 1h after the incision had been made. The lidocaine suppressed the development of flare formation without affecting the pain rating when the incision was made. The development of secondary hyperalgesia continued to be suppressed after completion of the lidocaine infusion.In experiment 2, post-traumatic treatment with lidocaine temporarily suppressed primary as well as secondary hyperalgesia that had fully developed; however, the primary and secondary hyperalgesia again became apparent after completion of the lidocaine administration.These findings suggest that pre-traumatic treatment with lidocaine reduces the excessive inputs from the injured peripheral nerves, thus suppressing development of flare formation and secondary hyperalgesia through peripheral and central mechanisms, respectively. Pre-traumatic treatment with lidocaine would temporarily stabilize the sensitized nerves in the injured area, but the nerves would be sensitized after completion of the administration. Post-traumatic treatment with lidocaine reduced primary and secondary hyperalgesia that had fully developed. However, the finding that the suppressive effect of lidocaine on secondary hyperalgesia was temporary suggests that the development and maintenance of secondary hyperalgesia are caused by different mechanisms.
PMID: 12435461, UI: 22323658
Pain 2002 Nov;100(1-2):55-64
Primary Care Sciences Research Centre, Hornbeam Building, Keele University, Staffordshire ST5 5BG, Keele, UK
This study has used the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) in an unsolicited postal questionnaire to investigate the impact of knee pain and disability in the general older population. The study provides WOMAC population data for those aged over 50 and demographic and psychosocial associations with severity of WOMAC scores. A pilot survey (n=240) and repeatability study (n=80) were undertaken to test completion of the WOMAC in this new setting. The main questionnaire was mailed to 8995 men and women aged over 50 registered with three general practices in North Staffordshire, UK. Completion rates for WOMAC items were high. Substantial reliability was found for pain and physical function scales (both >0.80). Fourteen percent of the over 50 population in this study had severe knee pain, 20% had severe difficulty with at least one area of physical functioning, 12% had both. The strongest link with severe difficulty with physical functioning was chronicity (odds ratio (OR)=6.49, 95% CI 4.65, 9.04). Other independent links were age over 75 years (odds ratio (OR)=4.11, 95% confidence interval (CI) 3.03, 5.58), depression (OR=2.80, 95% CI 2.22, 3.54), bilateral knee injury (OR=2.23, 95% CI 1.63, 3.06) and body mass index>30 (OR=2.00, 95% CI 1.51, 2.64). Similar associations were found for severe pain. The findings suggest that the WOMAC is a reliable measure for use in postal surveys. It has advantages over other instruments when measuring pain and physical function difficulty related to the knee. Chronicity, older age, injury, obesity and depression were all linked with higher WOMAC scores for knee pain severity and disability among knee pain sufferers in the general older population.
PMID: 12435459, UI: 22323656
Pain 2002 Nov;100(1-2):19-26
Laboratory for Experimental Pain Research, Center for Sensory-Motor Interaction (SMI), Aalborg University, Frederik Bajers Vej 7, D-3, DK-9220, Aalborg, Denmark
This study assessed spatial and temporal aspects of pressure pain during increasing and constant compressions using a cuff algometer and during adaptive compressions using a closed-loop feedback system for maintaining stable pain. Experimental setup consisted of a pneumatic tourniquet cuff, a computer-controlled air compressor, and a 10-cm electronic visual analogue scale (VAS). The first experiment assessed spatial summation for cuff pain by recording the pressure-pain stimulus-response (SR) function during increasing compressions with single and double cuffs. The second experiment assessed temporal profile of cuff pain during constant compression for 10min beginning at pain intensities of 2, 4, and 6cm on the VAS. The third experiment assessed temporal pressure profile when pain was maintained for 10min by a close-loop system within target zones of +/-0.5cm VAS at pain intensities of 2, 4, and 6cm on the VAS.Doubling the tissue volume under the cuff shifted the SR function to the left, demonstrating spatial summation. The constant cuff pressure evoked typical biphasic response consisting of an overshoot in pain intensity, followed by decreasing pain, or adaptation. The pain intensity was significantly correlated to the time of constant stimulation, showing time-dependency of pain encoding. Both overshoot magnitude and adaptation rate were dependent on the starting pain intensity. The pain decrease rate was lowest for a pain intensity of 2cm on the VAS. The overshoot magnitude was lowest for a pain intensity of 6cm on the VAS. Both the overshoot and the adaptation were maximal for a pain intensity of 4cm on the VAS. The oscillating pressure generated by closed-loop system led to constant rather than adapting pain at intensities of 2, 4, and 6cm on the VAS.The cuff algometer is highly configurable tool for assessment of pain sensitivity by pressure-pain and time-pain functions. The presented models are useful additions to a researcher's armamentarium for further pharmacological and clinical studies on deep tissue pain and related mechanisms.
PMID: 12435455, UI: 22323652
Pain 2002 Nov;100(1-2):1-6
Department of Oral and Craniofacial Biological Sciences, Program in Neuroscience, University of Maryland Dental School, 666 West Baltimore Street, Room 5A12, Baltimore, MD 21201, USA
PMID: 12435453, UI: 22323650
Spine 2002 Nov 1;27(21):2409-16
Institute for Research in Extramural Medicine, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands. hcw.de_vet.emgo@med.vu.nl
STUDY DESIGN: Literature review and group discussions. OBJECTIVE: To propose uniform definitions for low back pain episodes to be used in research. BACKGROUND: Different definitions of episodes have been used in low back pain studies. This hampers comparison of study results. Definitions are proposed for episodes of low back pain, care for low back pain, and work absence because of low back pain. METHODS: In a Medline search, we identified about 1200 papers, of which 81 possibly contained a definition of episodes. In group discussions, we decided which definitions to propose and discussed their applicability. RESULTS: We found few definitions in the literature. In the group discussions we decided to define an episode of LBP as a period of pain in the lower back lasting for more than 24 hours, preceded and followed by a period of at least 1 month without low back pain. An episode of care for low back pain was defined as a consultation or a series of consultations for low back pain, preceded and followed by at least 3 months without consultation for low back pain. An episode of work absence due to low back pain was defined as a period of work absence due to low back pain, preceded and followed by a period of at least 1 day at work. CONCLUSIONS: In many studies, episodes of low back pain are mentioned without a clear definition. We consider our proposed definitions of episodes to be arbitrary but well considered. We advise that they be tested for use in future research.
PMID: 12438991, UI: 22327371
Spine 2002 Nov 1;27(21):2383-9
Northwestern Health Sciences University, Bloomington, Minnesota 55431, USA. revans@nwhealth.edu
STUDY DESIGN: Randomized clinical trial. OBJECTIVES: To compare the effects of spinal manipulation combined with low-tech rehabilitative exercise, MedX rehabilitative exercise, or spinal manipulation alone in patient self-reported outcomes over a two-year follow-up period. SUMMARY OF BACKGROUND DATA: There have been few randomized clinical trials of spinal manipulation and rehabilitative exercise for patients with neck pain, and most have only reported short-term outcomes. METHODS: One hundred ninety-one patients with chronic neck pain were randomized to 11 weeks of one of the three treatments. Patient self-report questionnaires measuring pain, disability, general health status, improvement, satisfaction, and OTC medication use were collected after 5 and 11 weeks of treatment and 3, 6, 12, and 24 months after treatment. Data were analyzed taking into account all time points using repeated measures analyses. RESULTS: Ninety-three percent (178) of randomized patients completed the 11-week intervention phase, and 76% (145) provided data at all evaluation time points over the two-year follow-up period. A difference in patient-rated pain with no group-time interaction was observed in favor of the two exercise groups [F(2141) = 3.2; P= 0.04]. There was also a group difference in satisfaction with care [F(2143) = 7.7; P= 0.001], with spinal manipulation combined with low-tech rehabilitative exercise superior to MedX rehabilitative exercise (P = 0.02) and spinal manipulation alone (P < 0.001). No significant group differences were found for neck disability, general health status, improvement, and OTC medication use, although the trend over time was in favor of the two exercise groups. CONCLUSION: The results of this study demonstrate an advantage of spinal manipulation combined with low-tech rehabilitative exercise and MedX rehabilitative exercise versus spinal manipulation alone over two years and are similar in magnitude to those observed after one-year follow-up. These results suggest that treatments including supervised rehabilitative exercise should be considered for chronic neck pain sufferers. Further studies are needed to examine the cost effectiveness of these therapies and how spinal manipulation compares to no treatment or minimal intervention.
PMID: 12438988, UI: 22327368
Spine 2002 Nov 1;27(21):2346-9
Department of Orthopaedic Surgery, University of California San Francisco, 94143, USA. devirenv@orthosurg.ucsf.edu
STUDY DESIGN: A retrospective evaluation of radiographs in patients with idiopathic scoliosis was undertaken to assess predictors of flexibility. OBJECTIVE: To evaluate potential predictors of flexibility in patients with thoracolumbar and lumbar scoliosis. SUMMARY OF BACKGROUND DATA: Curve flexibility is an important consideration in the operative management of idiopathic scoliosis. Flexibility of the major curve is a useful predictor of expected surgical correction, and flexibility of compensatory curves determines whether they are structural or nonstructural. An accurate assessment of curve flexibility has important implications on surgical approaches and planning for deformity correction. The role of age and curve magnitude in predicting curve flexibility has not been well defined. A quantitative assessment of changes in curve flexibility with age and progression of deformity may yield important insight into the change in surgical management options over time. METHODS: A retrospective review of 75 patients with idiopathic thoracolumbar and lumbar scoliosis (age range 13-78 years) was undertaken. Preoperative standing and side-bending radiographs of thoracolumbar and lumbar curves were evaluated. Cobb angles of structural and fractional curves, curve flexibility, presence of lateral listhesis, and axial and radicular pain were documented. Predictors of structural and fractional curve flexibility were evaluated with correlation and regression analysis. Correlation analysis was used to demonstrate an association between radiographic findings and the clinical presentation. RESULTS: Seventy-five patients had an average major curve magnitude of 56 degrees (range 34-82 degrees ) with flexibility averaging 55% (range 20-93%). Structural curve flexibility was highly inversely correlated with both curve magnitude (r = -0.7; P< 0.001) and with age (r = -0.6; P< 0.001). Lumbar fractional curve (L4-S1) flexibility showed a high inverse correlation with age (r = -0.65; P< 0.001) but did not show correlation with Cobb angle. Thoracic compensatory curves showed a moderate correlation with Cobb angle (r = 0.53). Structural and fractional curve flexibility showed high correlation with each other (r = 0.5-0.66). Regression analysis yielded a formula to predict the flexibility of the structural curve (FSC): FSC = 130 - (Cobb + Age/2). Axial pain was correlated with age (r = 0.63); however, it was not correlated with curve magnitude. CONCLUSION: We have shown that curve magnitude and patient age are the main predictors of structural flexibility. Every 10 degrees increase in curve magnitude over 40 degrees results in a 10% decrease in flexibility; every 10-year increase in age decreases flexibility of the structural curve by 5% and the lumbosacral fractional curve by 10%. Curve magnitude and age of the patients are significant predictors of curve flexibility. The demonstration of this association offers useful information in estimating how surgical options for deformity correction may change over time.
PMID: 12438982, UI: 22327362
Spine 2002 Nov 15;27(22):E493-5
Department of Radiology at the University Hospital of Geneva, Geneva, Switzerland. stephanwetzel@yahoo.de
STUDY DESIGN: Technical note. OBJECTIVE: To describe a technique for performing percutaneous vertebroplasty of C1 for treatment of osteolytic metastatic disease involving the lateral portions of the atlas in which precautions are taken to protect the vertebrobasilar arterial supply and a posterior access route is used for cement delivery. SUMMARY OF BACKGROUND DATA: Percutaneous vertebroplasty (PVP) has proved to be efficient for the treatment of painful osteolytic vertebral disease. Good clinical experience with this technique suggested its extension to stabilize a painful osteolytic lesion of the atlas. METHODS: A patient with known parotid cancer presented with neck pain refractory to conservative treatment. On computed tomography, osteolytic destruction of the atlas that mainly involved the right lateral mass and surrounded the vertebral artery was found. On digital subtraction angiography, the lesion was shown to be highly vascularized and supplied mainly by direct branches of the ipsilateral vertebral artery. To avoid the risk of cement reflux from the tumor vascular bed to the involved vertebral artery, coil occlusion of the involved V3 segment was performed before vertebroplasty. Percutaneous vertebroplasty was then carried out using a percutaneous posteroanterior direction access route. RESULTS: Satisfactory filling of the osteolytic lesion with cement was achieved radiologically. Three days after the intervention and at a 9-month follow-up examination, the patient was free of pain. CONCLUSIONS: Vertebroplasty used to treat an osteolytic lesion of the atlas involving the lateral mass was performed by a posterior percutaneous approach. To prevent vertebrobasilar embolism, the involved vertebral artery was occluded before polymer injection.
PMID: 12436010, UI: 22323897
Spine 2002 Nov 15;27(22):E478-81
Department of Anesthesiology and Reanimation, Gazi University Medical Faculty, Ankara, Turkey. mahli@med.gazi.edu.tr
STUDY DESIGN: Harvesting of autologous bone graft from the posterior iliac crest for lumbar spinal fusions is a frequently performed procedure in orthopedic surgery. The most common complication associated with this procedure is an alteration in sensation over the donor site manifested as chronic pain, hyperesthesia, dysesthesia, or diminished sensitivity resulting from superior cluneal nerve (SCN) injury. OBJECTIVE: To predict the effectiveness of alcohol neurolysis in the treatment of persistent pain caused by the entrapment of superior cluneal nerves. SUMMARY AND BACKGROUND DATA: The subjects of this study were patients with intractable pain in donor area after conventional treatments using a transverse incision, which is parallel to posterior iliac crest. The study group was composed of four patients who underwent surgery in a 1-year period and experienced chronic pain resulting from superior cluneal nerve injury. METHODS: No reports describing alcohol neurolysis of the superior cluneal nerve exist in the relevant literature. All four patients in this study were treated with alcohol neurolysis of the superior cluneal nerves. RESULTS: The study patients were observed up to 4 years, and none of them reported any problems. CONCLUSIONS: The authors suggest that conventional treatments be limited to a 2-month period, and that alcohol neurolysis be applied as soon as possible to prevent lengthy pain experiences.
PMID: 12436006, UI: 22323893
Spine 2002 Nov 15;27(22):2621-6
Section of Orthopaedic Surgery and Rehabilitation and Anesthesia and Critical Care, University of Chicago Spine Center, Chicago, Illinois 60640, USA. twetzel@mcis.bsd.uchicago.edu
STUDY DESIGN: Retrospective literature review. OBJECTIVES: To review the data on the clinical efficacy of intradiscal electrothermal annuloplasty found at this writing in the peer-reviewed literature to date, to discuss the methodologic strengths and flaws of the studies, to discuss the pitfalls of clinical study designs, to emphasize the need for prospective randomized studies and for increased basic science investigation. SUMMARY OF BACKGROUND DATA: Studies published or presented at peer-reviewed societies concerning the clinical efficacy of intradiscal electrothermal annuloplasty are reviewed, including background studies on deafferentation and application of thermal energy to alter biomechanical and structural properties. A proposal for future investigations is presented. METHODS: Background data from intracapsular annuloplasty highlighting the safety and efficacy of intradiscal electrothermal annuloplasty are presented. Current studies on this procedure, including those in the National Registry are reviewed. All the studies share a common study design: prospective cohort with historical or noninterventional groups used as controls. The patients reviewed are similar. All have nonradicular low back pain of at least 3 months duration, failed conservative care, normal neurologic examination, and MRI showing only nondegenerative disc disease and positive concordant discography. All the patients underwent intradiscal electrothermal annuloplasty lesion at one or two levels according to standard protocols. Follow-up evaluation was performed at various intervals up to 2 years. All the studies used data from a visual analog scale, with most using the Short Form 36 (SF-36) as outcome instruments. RESULTS: The reported follow-up periods for the studies ranged from 6 months to 2 years. Three published studies, one with a 6-month follow-up period and two with a 1-year follow-up period, were published in the peer-reviewed literature. Two recent reports presented to the North American Spine Society were reviewed: a study of patients on a manufacturer-sponsored registry with a 1-year follow-up period and a multicenter prospective cohort study of 75 patients in an intent-to-treat group, with a 1-year follow-up period. Using the 7-point criteria of Deyo et al, all the studies suggested a positive effect of treatment, with a decrease in visual analog scale ratings and improvement in SF-36 scales, particularly those for physical function and bodily pain. CONCLUSIONS: The studies published so far suggest that the pain resulting from lumbar disc disease may be diminished by intradiscal electrothermal annuloplasty. All these studies project a positive therapeutic effect. However, all the studies suffer from the same methodologic flaws. A prospective cohort design or a nonrandomized prospective design is used with a biased control. The scientific validity of various study designs is discussed, and a randomized prospective study is recommended. Additionally, more investigation into the basic science of the action of intradiscal electrothermal annuloplasty is required.
PMID: 12436005, UI: 22323892
Spine 2002 Nov 15;27(22):2614-9; discussion 2620
North Georgia Pain Clinic, Canton, Georgia 30114, USA. NGPCDHS@aol.com
The cost of chronic benign spinal pain is large and growing. The costs of interventional treatment for spinal pain were at a minimum of $13 billion (U.S. dollars) in 1990, and the costs are growing at least 7% per year. Medical treatment of chronic pain costs $9000 to $19,000 per person per year. The costs of interventional therapy is calculated. Methods of evaluating differential treatments in terms of costs are described. Cost-minimization versus cost-effectiveness approaches are described. Spinal cord stimulation and intraspinal drug infusion systems are alternatives that can be justified on a cost basis. Cost minimization analysis suggests that epidural injections under fluoroscopy may not be justified by the current literature.
PMID: 12436003, UI: 22323890
Spine 2002 Nov 15;27(22):2607-12; discussion 2613
Department of Neurosurgery, University of Tennessee, Memphis, Tennessee 38104, USA.
STUDY DESIGN: The literature on current neuroablative techniques for treating benign chronic painful conditions is comprehensively reviewed. OBJECTIVE: To provide the reader with an understanding of the indications, techniques, and outcomes for the various ablative procedures used to treat chronic pain syndromes. SUMMARY OF BACKGROUND DATA: Neuromodulatory techniques are rapidly supplanting the traditional neuroablative procedures used to treat many types of pain. METHODS: A MEDLINE search was conducted for each of the following procedures: radiofrequency facet denervation, cordotomy, myelotomy, sympathectomy, DREZotomy, rhizotomy, and ganglionectomy. In the review of each article, special attention given to the outcome, length of follow-up, complications, and number of patients. Summaries of this data were compiled to provided historical perspective, current techniques, indications, and outcomes for each of the aforementioned procedures. The outcomes cited for each procedure generally represent the data from the three or four largest series with adequate follow-up length. RESULTS: The aforementioned procedures have 30% to 90% success rates, with success defined as at least a 50% reduction in perceived pain. These results tend to diminish with time. However, most are associated with a significant degree of morbidity and relatively high complication rates. In addition, many of the techniques lead to deafferentation pain syndromes. CONCLUSIONS: Ablative spinal techniques offer pain relief for many patients, but the use of these methods should be considered carefully in the light of available nondestructive procedures that may achieve similar goals with potentially lower morbidities.
PMID: 12436001, UI: 22323888
Spine 2002 Nov 15;27(22):2593-605; discussion 2606
California Pain Medicine Centers and Reflex Sympathetic Dystrophy Institute and the University of California at Los Angeles School of Medicine, Los Angeles, California, USA. paindoc@UCLA.edu
STUDY DESIGN: A literature review and synthesis were performed. OBJECTIVE: To summarize the history, use, and innovation related to neuraxial drug delivery for the treatment of intractable back pain. SUMMARY OF BACKGROUND DATA: The discovery of opioid receptors in the early 1970s provided a rational basis for the delivery of opioid drugs intraspinally. Epidural or intrathecal infusions deliver drugs directly to opioid receptors, limit systemic exposure, and by decreasing the opioid dosage required for pain relief, generally reduce side effects. The benefits of short-term spinal analgesia led to investigation of longer-term continuous subarachnoid opioid infusions for the management of both cancer pain and noncancer pain, such as that of spinal origin. METHODS: RESULTS: Unique features of this article include an updated pain continuum, updated indications for intrathecal therapy, a detailed comparison of trial techniques, a detailed comparison of the advantages of different types of pumps, a synopsis of troubleshooting for inadequate efficacy, and an updated statement regarding intrathecal pumps and radiologic procedures, including MRI scanning. Some challenges remain. Large-scale well-controlled studies could answer some perplexing questions regarding efficacy in patients with noncancer or neuropathic pain. Patient selection criteria undoubtedly will be refined and validated as more patients are treated. In addition, further investigation of specifically targeted medications or drug combinations for intraspinal use could increase efficacy, reduce side effects, and expand indications. CONCLUSIONS: Intraspinal medication delivery has become an effective technique for control of intractable pain in appropriately selected patients seen by spine surgeons.
PMID: 12435999, UI: 22323886
Spine 2002 Nov 15;27(22):2584-91; discussion 2592
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. rnorth@jhmi.edu
STUDY DESIGN: A literature review was conducted. OBJECTIVE: To review the indications and efficacy of spinal cord stimulation, particularly in reference to chronic pain of spinal origin. SUMMARY OF BACKGROUND DATA: The first spinal cord stimulation was implanted by Shealy in 1967 via a subarachnoid route. Early systems were plagued with a high rate of complications and technical problems. With the evolving technology, especially the advent of multichannel programmable systems and more precise epidural placement, the ability of spinal cord stimulation to treat various pain syndromes improved. This article reviews the literature on spinal cord stimulation from 1967 to the present. METHODS: The literature is reviewed, with a particular focus on recent studies investigating the efficacy of spinal cord stimulation for low back pain. RESULTS: Most studies are limited by the same flaws, namely, retrospective study design. At this writing, the few published randomized prospective studies have suggested that spinal cord stimulation may be superior to repeat surgery. Complication rates have declined to approximately 8%, and reoperation is necessary in approximately 4% of patients. When current percutaneous techniques are used, a lead migration rate lower than 3% may be achieved. For certain topographies, laminotomy leads may be superior, particularly with regard to low back pain. CONCLUSIONS: The ultimate efficacy of spinal cord stimulation remains to be determined, primarily because of limitations associated with the published literature. However, on the basis of the current evidence, it may represent a valuable treatment option, particularly for patients with chronic pain of predominantly neuropathic origin and topographical distribution involving the extremities. The potential treatment of other pain topographies and etiologies by spinal cord stimulation continues to be studied.
PMID: 12435997, UI: 22323884
Spine 2002 Nov 15;27(22):2564-73
Royal National Hospital for Rheumatic Diseases and University of Bath, United Kingdom. Lance.McCracken@RNHRD-tr.swest.nhs.uk
STUDY DESIGN: A literature review was conducted. OBJECTIVE: To examine the outcome of behavioral (BT) and cognitive-behavioral treatment (CBT), collectively referred to as BT-CBT, for chronic pain, to identify the predictors of treatment outcome, and to investigate the change processes associated with these treatments. SUMMARY OF BACKGROUND DATA: Numerous controlled clinical trials of BT-CBT for chronic pain, alone or more commonly in multidisciplinary treatment contexts, suggest that these treatments are effective. However, further study is needed to examine which outcome variables change, when, for whom, and how. METHODS: Published literature was gathered from Medline, PsychLit, and searches of relevant journals. RESULTS: Overall, BT-CBT for chronic pain reduces patients' pain, distress, and pain behavior, and improves their daily functioning. Differences across studies in sample characteristics, treatment features, and assessment methods seem to produce varied treatment results. Also, some patients benefit more than others. Highly distressed patients who see their pain as an uncontrollable and highly negative life event derive less benefit than other patients. Decreased negative emotional responses to pain, decreased perceptions of disability, and increased orientation toward self-management during the course of treatment predict favorable treatment outcome. CONCLUSIONS: Current BT-CBT helps many patients with chronic pain. Continuing clinical research should improve the matching of treatments with patient characteristics and refine the focus of treatments on behavior changes most associated with positive outcome. Further study of fear, attention, readiness to adopt self-management strategies, acceptance of pain, and new combinations of interdisciplinary treatments may lead to improved interventions.
PMID: 12435995, UI: 22323882
Spine 2002 Nov 15;27(22):2555-62; discussion 2563
SpineCare Medical Group, San Francisco Spine Institute, Daly City, California 94015, USA. pslosar@spinecare.com
STUDY DESIGN: Peer-reviewed literature was reviewed and summarized. OBJECTIVE: To synthesize the indications and published outcomes of reconstructive lumbar spine surgery for the treatment of chronic pain of spinal origin. METHODS: A literature review was conducted. RESULTS: The most common indication for reconstructive lumbar surgery is pain that is refractory to nonsurgical treatment. Lumbar fusion has been shown to improve symptoms in carefully selected patients with incapacitating pain. CONCLUSIONS: A successful arthrodesis is the fundamental surgical goal for patients with chronic pain of spinal origin. However, a successful fusion does not always correlate with a successful clinical result.
PMID: 12435993, UI: 22323880
Spine 2002 Nov 15;27(22):2547-53; discussion 2554
University of Chicago Spine Center, Section of Orthopaedic Surgery, Chicago, Illinois 60640, USA. fphillip@weisshospital.org
STUDY DESIGN: A literature review was conducted. OBJECTIVE: To provide an evidence-based approach for patients with neurogenic symptoms after lumbar surgery. SUMMARY OF BACKGROUND DATA: Patients may present with chronic pain of spinal origin after lumbar surgery. Failure to decompress the involved neural structures adequately or progression of the underlying degenerative condition may lead to neurologic symptoms. METHODS: A literature search of peer-reviewed publications that investigate etiologies and treatments for neurogenic pain in patients who have undergone previous spinal surgery was conducted. RESULTS: In the absence of profound or progressive neurologic deficits, most patients with chronic back and leg pain who have undergone previous spinal surgery should be treated nonoperatively. Additional decompressive surgical intervention may be justified in patients with well-defined, discrete pathology amenable to surgical correction who have been refractory to conservative care. The surgery typically will include meticulous decompression of the affected neural structures and may include arthrodesis to address any deformity or instability. CONCLUSIONS: In a patient presenting with neurogenic symptoms after lumbar surgery, a meticulous workup is required to elucidate the source of these symptoms. Surgical indications are similar to those for primary lumbar spinal surgery and include a well-defined anatomic source of neural compression that is amenable to a surgical solution.
PMID: 12435991, UI: 22323878
Spine 2002 Nov 15;27(22):2538-45; discussion 2546
SOAR, Physiatry Medical Group, Redwood City, California 94063, USA. jssaal@aol.com
STUDY DESIGN: The literature on diagnostic tests available to the spine clinician for the evaluation of chronic low back pain was reviewed. OBJECTIVES: To review critically the available information and data on invasive diagnostic tests used for evaluation of chronic low back pain. SUMMARY OF BACKGROUND INFORMATION: Numerous published studies have described the technique and clinical results of diagnostic blocks for chronic low back pain. There are various methodologies, but most lack of an adequate "gold standard" with which to compare the results of the diagnostic test. METHODS: The available published studies of diagnostic tests commonly used in the evaluation of chronic low back pain were reviewed, with a focus on invasive techniques. The techniques were evaluated on the basis of the data available to support the conclusions that could be drawn for each of these techniques. The principles of diagnostic testing, including specificity and sensitivity, were reviewed and applied in the context of the data available for each of these invasive tests. RESULTS: The essential features the clinician seeks in a diagnostic test are accuracy, safety, and reproducibility. It is essential to have a gold standard with which to compare the accuracy of a given diagnostic test. There is no completely reliable gold standard with which to compare a diagnostic test (or injection) when the absence of pain is the end point. The clinical setting in which the test is used directly affects the test results. The prevalence of the disease therefore affects the meaningfulness of the test results. Imaging studies have their greatest value in the exclusion of other conditions. These studies alone were not adequate for predicting the patients who would respond to controlled diagnostic blocks of the facet joint. Facet joint diagnostic blockade probably is most accurately performed by median nerve branch block. The greatest specificity for a positive response to a facet denervation procedure is achieved when the diagnosis is established via highly controlled anesthetic blocks. Over the past few decades, the sacroiliac joint has received varying degrees of interest as an important pain generator of low back pain. Despite testimonials to the contrary, no diagnostic physical examination has correlated with sufficient specificity to diagnose this condition reliably from a clinical standpoint. Lumbar discography has been one of the single most controversial subjects in the management of degenerative, painful lumbar spine conditions. The specificity and sensitivity are high for the diagnosis of disc degeneration. The question that revolves around discography concerns the accuracy of this test for the diagnosis of discogenic pain. An integral part of the problem is the lack of an adequate gold standard. In a comparison of nerve root blockade, sciatic nerve block, posterior ramus block, and subcutaneous injection in a cohort of patients with sciatica, the sensitivity of nerve root block was very high, with only a moderate level of specificity. In the case of diagnostic selective nerve blocks used for evaluation of complex or protean nerve compression, surgical confirmation and clinical results should be a reliable gold standard. Conflicting results have been presented depending on the target lesion and method of study. CONCLUSIONS: There are inherent limitations in the accuracy of all diagnostic tests. The tests used to diagnose the source of a patient's chronic low back pain require accurate determination of the abolition or reproduction of the patient's painful symptoms.
PMID: 12435989, UI: 22323876
Spine 2002 Nov 15;27(22):2526-37
Department of Anesthesiology, Dartmouth-Hitchcock Medical Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA. joyce.a.deleo@hitchcock.org
STUDY DESIGN: The literature and current research related to spinal pain mechanisms were reviewed, as well as animal models related to its study. OBJECTIVES: To provide a pragmatic discussion of spinal pain that both reviews relevant research and coherently synthesizes the existing body of literature related to pain, nociception, animal modeling, and injury biomechanics. SUMMARY OF BACKGROUND DATA: A detailed body of literature suggests that spinal pain mechanisms are quite complicated and involve a host of different processes (e.g., genetics, gender, neurophysiology, and biomechanics) that may contribute to clinical manifestations and symptoms. METHODS: Both a review of the literature and a presentation of current and ongoing laboratory research are presented. Specific findings from the authors' laboratory using a rodent model of lumbar radiculopathy are presented to elucidate the role of local nerve root biomechanics in initiating and maintaining behavioral symptoms of nociception and pain. RESULTS: For an understanding of chronic pain, a bidirectional-translational approach that incorporates cross-disciplinary methods such as in vivo biomechanical techniques is required. A conceptual model of chronic spine pain is proposed that details the dynamic and integrated roles of injury, biomechanics, and nociceptive physiology. CONCLUSIONS: Areas of continued research are highlighted that may help guide the management of painful spine symptoms and syndromes.
PMID: 12435988, UI: 22323875
Spine 2002 Nov 15;27(22):2523
[Record supplied by publisher]
Publication Types:
PMID: 12435986
Support Care Cancer 2002 Nov;10(8):637-46
Leukaemia Foundation's Psycho-social Research Program, Department of Religion, School of History, Philosophy, Religion and Classics, University of Queensland, St Lucia, Qld 4072, Australia, pam.mcgrath@bigpond.com
The findings presented in this discussion seek to make a contribution to fostering an appreciation of the importance of research on spirituality, a previously neglected dimension of health care. Qualitative research methodology based on open-ended interviews with 12 survivors of haematological malignancies was used. The interviews were transcribed verbatim and thematically analysed using the NUD*IST computer package. The preliminary findings from the study indicate a need for the development of a new language for articulating spirituality. The present discussion is an introductory attempt to begin to explore the notion of, and language for, the idea of 'spiritual pain'. The findings indicate that individuals need a strong sense of meaning-making and connection with life to be able to deal with the demands of aggressive, invasive treatments. Such a connection can be threatened by a break with the normal or expected relationships and satisfaction with life through physical, identity, relational and existential challenges and losses. When the disconnection is acutely painful (a subjective phenomenon depending on the individual) it then is experienced as spiritual pain, creating a void that challenges the individual's ability to derive any meaning from their existence. This study is seen as preliminary work, the first step in a series of articles aimed at beginning to develop, through research, a language of spiritual care.
PMID: 12436223, UI: 22323921