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Cephalalgia 2002 Oct;22(8):664-6
Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark, and Merck Research Laboratories, West Point, PA, USA.
[Medline record in process]
Sum of Pain Intensity Difference (SPID) is an outcome measure that summarizes treatment response over a clinically relevant period. SPID is widely reported in clinical trials of analgesics but has been little used in migraine trials. We compared SPID over 2 h with the standard migraine outcome measures of pain-free at 2 h and headache relief at 2 h using data from four published clinical trials of rizatriptan in migraine patients. In assessing treatment response (rizatriptan and sumatriptan versus placebo, rizatriptan versus sumatriptan, within-treatment dose effects), SPID usually yielded similar results to the more easily understood pain-free measure.
PMID: 12383062, UI: 22271267
Other Formats:
J Pain Symptom Manage 2002 Aug;24(2):208-10
National Medical University of Mongolia, Ulaanbaatar, Mongolia.
Publication Types:
PMID: 12231147, UI: 22218344
J Pain Symptom Manage 2002 Aug;24(2):152-9
Pain & Policy Studies Group, University of Wisconsin-Madison Comprehensive Cancer Center, and World Health Organization Collaborating Center for Policy and Communications in Cancer Care, Madison, WI 53711, USA.
PMID: 12231133, UI: 22218330
Lancet 2002 Sep 28;360(9338):1002
PMID: 12383675, UI: 22272042
Neurology 2002 Sep 24;59(6 Suppl 4):S56-61
502 North, IOP, Department of Psychiatry, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA.
Over the past 5 years, and especially within the last year, there has been a rapid expansion of vagus nerve stimulation (VNS)-related preclinical research, as well as clinical studies in indications other than epilepsy. The research advances in understanding VNS are occurring in the midst of a blossoming of other forms of therapeutic brain stimulation, such as electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), and deep brain stimulation (DBS). In general, improved understanding of the neurobiological effects of VNS therapy as a function of the different use parameters (frequency, intensity, pulse width, duration, dose) is beginning to guide clinical use and help determine which diseases, in addition to epilepsy, VNS might treat.
PMID: 12270970, UI: 22232009
Rheum Dis Clin North Am 2002 Aug;28(3):669-85
Department of Pediatrics, University of Pennsylvania, 3101 Walnut Street, Philadelphia, PA 19104, USA. dsherr@chmc.org
Idiopathic musculoskeletal pain syndromes in children have a variety of manifestations; they can be diffuse or well localized, constant or intermittent, with or without autonomic symptoms and signs, completely incapacitating or not limiting activities, and they can tax the physician's diagnostic skill. A careful history and examination is usually all that is needed to make a diagnosis, although the differential diagnosis is large and might require laboratory and radiographic investigation. Pain and functional assessment help track the progress with therapy. Intense exercise therapy is associated with the best outcome. Psychologic issues should be evaluated to determine if further psychologic intervention is indicated. The medium-term outcome is probably good for most of these children, but the long-term prognosis is unknown. One must be aware that other manifestations of psychologic problems might emerge. By the time these children and their families see the rheumatologist they are desperate and can be frustrating to work with due to their difficulty in accepting any kind of psychologic element to the pain and its associated disability. Nevertheless, it is rewarding to help the children understand and work through their pain so they can resume normal lives.
PMID: 12380375, UI: 22268582
Stereotact Funct Neurosurg 2001 Oct;77(1-4):177-182
Stereotactic and Functional Neurosurgery Service and Department of Gynecology of Hospital das Clinicas, Medical School, Universidade Federal de Goias; and Stereotactic and Functional Neurosurgery Service of Instituto do Cerebro de Goiania, Goiania, GO, Brazil.
[Record supplied by publisher]
Surgical treatment of intractable visceral pain has always been a challenge. The relatively recent discovery of a specific visceral pain pathway brought a new insight to this matter. The authors describe a new technique to interrupt this pathway, the CT-guided percutaneous punctate midline myelotomy, successfully applied in two patients with intractable pelvic visceral pain. Due to its simplicity, safety and high effectiveness, it may become the treatment of choice for intractable visceral pain. Copyright 2002 S. Karger AG, Basel
PMID: 12378073
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